deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT02705859

Phase Ib/II Trial of coPANlisib in Combination With Trastuzumab in HER2-positive Breast Cancer. (Panther Study) (Panther)

Phase Ib/II Clinical Trial of Copanlisib in Combination With Trastuzumab in Pretreated Recurrent or Metastatic HER2-positive Breast Cancer

Sponsor: Cancer Trials Ireland

Conditions HER2 Positive Breast Cancer
Interventions Copanlisib Trastuzumab
Updated 13 times since 2017 Last updated: Jan 8, 2025 Started: Apr 30, 2016 Primary completion: May 31, 2021 Completion: Jul 31, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates HER2 Positive Breast Cancer and is currently completed. Cancer Trials Ireland leads this study, which shows 13 recorded versions since 2016 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Jun 2018 · 17 months · monthly snapshot~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshot~Mar 2019 – ~Sep 2019 · 6 months · monthly snapshot~Sep 2019 – ~May 2020 · 8 months · monthly snapshot~May 2020 – ~Jan 2021 · 8 months · monthly snapshot~Jan 2021 – ~Nov 2021 · 10 months · monthly snapshot~Nov 2021 – ~Sep 2022 · 10 months · monthly snapshot~Sep 2022 – ~Dec 2023 · 15 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Sep 2025 · 7 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

13 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1

  2. Feb 2025 — Sep 2025 [monthly]

    Completed PHASE1

  3. Sep 2024 — Feb 2025 [monthly]

    Completed PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  5. Dec 2023 — Jul 2024 [monthly]

    Completed PHASE1

▶ Show 8 earlier versions

  1. Sep 2022 — Dec 2023 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Nov 2021 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  3. Jan 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  4. May 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  5. Sep 2019 — May 2020 [monthly]

    Recruiting PHASE1

  6. Mar 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  7. Jun 2018 — Mar 2019 [monthly]

    Recruiting PHASE1

  8. Jan 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

    First recorded

Apr 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Cancer Trials Ireland
Data source: Cancer Trials Ireland

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations