deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 1-arm NCT02707458

Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration (DEPEND)

Dose-finding and Proof-of-concept Trial of Probucol to Increase Availability of CSF Apolipoprotein-E

Sponsor: Douglas Mental Health University Institute

Conditions Age-related Cognitive Decline Dementia of the Alzheimer Type Mild Cognitive Impairment Due to Alzheimer Disease
Interventions Probucol
Updated 7 times since 2017 Last updated: Jan 30, 2018 Started: Apr 30, 2016 Primary completion: Mar 31, 2017 Completion: Mar 31, 2017
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Age-related Cognitive Decline and Dementia of the Alzheimer Type and is currently completed. Douglas Mental Health University Institute leads this study, which shows 7 recorded versions since 2016 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotNot Yet Recruiting~Feb 2017 – ~Feb 2018 · 12 months · monthly snapshotNot Yet Recruiting~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshotCompleted~Jun 2018 – ~Jan 2021 · 31 months · monthly snapshotCompleted~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – present · 22 months · monthly snapshotCompleted

Change History

7 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  3. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

  4. Jun 2018 — Jan 2021 [monthly]

    Completed PHASE1_PHASE2

  5. Feb 2018 — Jun 2018 [monthly]

    Completed PHASE1_PHASE2

    Status: Not Yet Recruiting → Completed

▶ Show 2 earlier versions

  1. Feb 2017 — Feb 2018 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  2. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Apr 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Douglas Mental Health University Institute
  • McGill University
  • Weston Brain Institute
Data source: Douglas Mental Health University Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations