deltatrials
Completed PHASE1 INTERVENTIONAL 8-arm NCT02736565

Pbi-shRNA™ EWS/FLI1 Type 1 LPX in Subjects With Advanced Ewing's Sarcoma

Phase I Trial of Pbi-shRNA™ EWS/FLI1 Type 1 Lipoplex (LPX) in Subjects With Advanced Ewing's Sarcoma

Sponsor: Gradalis, Inc.

Conditions Ewing Family of Tumors Ewing's Sarcoma Ewing's Sarcoma Metastatic Ewing's Tumor Metastatic Ewing's Tumor Recurrent Rare Diseases Sarcoma
Interventions pbi-shRNA™ EWS/FLI1 Type 1 Lipoplex
Updated 20 times since 2017 Last updated: Nov 9, 2023 Started: Oct 31, 2016 Primary completion: Aug 12, 2019 Completion: Aug 4, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Ewing Family of Tumors and Ewing's Sarcoma, this trial is completed. The trial is conducted by Gradalis, Inc. and has accumulated 20 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2018 · 13 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Mar 2019 · 5 months · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Feb 2020 · 7 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~Aug 2020 · 4 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Nov 2021 · 8 months · monthly snapshot~Nov 2021 – ~Apr 2022 · 5 months · monthly snapshot~Apr 2022 – ~May 2023 · 13 months · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Dec 2023 · 4 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

20 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Dec 2023 — Jul 2024 [monthly]

    Completed PHASE1

  4. Aug 2023 — Dec 2023 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  5. May 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

▶ Show 15 earlier versions

  1. Apr 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  2. Nov 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  3. Mar 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1

  4. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE1

  5. Aug 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  6. Apr 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  7. Feb 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  8. Jul 2019 — Feb 2020 [monthly]

    Recruiting PHASE1

  9. Apr 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  10. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  11. Oct 2018 — Mar 2019 [monthly]

    Recruiting PHASE1

    Status: Active Not Recruiting → Recruiting

  12. Jun 2018 — Oct 2018 [monthly]

    Active Not Recruiting PHASE1

  13. Mar 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  14. Feb 2017 — Mar 2018 [monthly]

    Recruiting PHASE1

  15. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Oct 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Gradalis, Inc.
Data source: Gradalis, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations