deltatrials
Completed PHASE1 INTERVENTIONAL 18-arm NCT02740985

A Phase 1 Clinical Study of AZD4635 in Patients With Advanced Solid Malignancies

A Phase 1, Open-Label, Multicenter Study to Assess Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-Tumor Activity of Ascending Doses of AZD4635 Both as Monotherapy and in Combination in Patients With Advanced Solid Malignancies

Sponsor: AstraZeneca

Conditions Advanced Solid Malignancies Colorectal Carcinoma (CRC) Metastatic Castrate-Resistant Prostate Carcinoma (mCRPC) Non-Small Cell Lung Cancer (NSCLC)
Interventions AZD4635 Abiraterone Acetate Docetaxel Durvalumab Enzalutamide Oleclumab
Updated 40 times since 2017 Last updated: May 25, 2023 Started: Jun 17, 2016 Primary completion: Dec 31, 2020 Completion: Mar 31, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02740985, this PHASE1 trial focuses on Advanced Solid Malignancies and Colorectal Carcinoma (CRC) and remains completed. Sponsored by AstraZeneca, it has been updated 40 times since 2016, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Dec 2017 · 7 months · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Mar 2019 · 4 months · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Jun 2021 · 3 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Mar 2022 · 3 months · monthly snapshot~Mar 2022 – ~Jun 2022 · 3 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jun 2023 · 6 months · monthly snapshot~Jun 2023 – ~Jul 2024 · 13 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

40 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Jun 2023 — Jul 2024 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  4. Dec 2022 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

▶ Show 35 earlier versions

  1. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  2. Mar 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1

  3. Dec 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  4. Sep 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1

  5. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  6. Mar 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE1

  7. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE1

  8. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  9. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  10. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  11. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  12. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  13. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  14. Feb 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  15. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  16. Nov 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  17. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  18. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  19. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  20. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  21. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  22. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  23. Nov 2018 — Mar 2019 [monthly]

    Recruiting PHASE1

  24. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  25. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  26. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  27. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  28. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  29. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE1

  30. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE1

  31. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE1

  32. May 2017 — Dec 2017 [monthly]

    Recruiting PHASE1

  33. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE1

  34. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE1

  35. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Jun 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
Data source: AstraZeneca

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Chattanooga, United States , Daytona Beach, United States , Decatur, United States , Denver, United States , Durham, United States , Fayetteville, United States , Fresno, United States , Las Vegas, United States , Lecanto, United States , Myrtle Beach, United States and 7 more locations