deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT02741791

A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Treatment Resistant Major Depressive Disorder (STRIDE-1)

STRIDE-1: A Randomized, Double-blind, Active-controlled Trial to Assess the Efficacy and Safety of AXS-05 Administered Orally to Subjects With Treatment Resistant Major Depressive Disorder

Sponsor: Axsome Therapeutics, Inc.

Interventions AXS-05 Bupropion
Updated 16 times since 2017 Last updated: Mar 22, 2021 Started: Mar 31, 2016 Primary completion: Mar 20, 2020 Completion: Mar 20, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Treatment Resistant Major Depressive Disorder, this trial is completed. The trial is conducted by Axsome Therapeutics, Inc. and has accumulated 16 data snapshots since 2016. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Sep 2017 · 7 months · monthly snapshot~Sep 2017 – ~Mar 2018 · 6 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Oct 2018 · 3 months · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Feb 2020 · 14 months · monthly snapshot~Feb 2020 – ~Nov 2020 · 9 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Apr 2022 · 12 months · monthly snapshot~Apr 2022 – ~Jul 2024 · 27 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

16 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Apr 2022 — Jul 2024 [monthly]

    Completed PHASE3

  5. Apr 2021 — Apr 2022 [monthly]

    Completed PHASE3

Show 11 earlier versions
  1. Jan 2021 — Apr 2021 [monthly]

    Completed PHASE3

  2. Nov 2020 — Jan 2021 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  3. Feb 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  4. Dec 2018 — Feb 2020 [monthly]

    Recruiting PHASE3

  5. Oct 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  6. Jul 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  7. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  8. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  9. Sep 2017 — Mar 2018 [monthly]

    Recruiting PHASE3

  10. Feb 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  11. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Mar 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Axsome Therapeutics, Inc.
Data source: Axsome Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .