deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT02756572

Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid Neoplasms

A Feasibility Study of Early Allogeneic Hematopoietic Cell Transplantation for Relapsed or Refractory High-Grade Myeloid Neoplasms

Sponsor: National Cancer Institute (NCI)

Conditions Blasts 10 Percent or More of Bone Marrow Nucleated Cells Chronic Myelomonocytic Leukemia-2 High Grade Malignant Neoplasm Myelodysplastic Syndrome Myelodysplastic Syndrome With Excess Blasts-2 Myeloid Neoplasm Previously Treated Myelodysplastic Syndrome Recurrent Acute Myeloid Leukemia Refractory Acute Myeloid Leukemia
Interventions Allogeneic Hematopoietic Stem Cell Transplantation Cladribine Cyclosporine Cytarabine Filgrastim Fludarabine Phosphate Laboratory Biomarker Analysis Melphalan Melphalan Hydrochloride Mitoxantrone Hydrochloride Mycophenolate Mofetil Questionnaire Administration Sirolimus Total-Body Irradiation
Updated 21 times since 2017 Last updated: Oct 11, 2021 Started: Sep 22, 2016 Primary completion: Mar 1, 2020 Completion: Jul 1, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Blasts 10 Percent or More of Bone Marrow Nucleated Cells and Chronic Myelomonocytic Leukemia-2, this trial is completed. The trial is conducted by National Cancer Institute (NCI) and has accumulated 21 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Aug 2017 · 5 months · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Feb 2018 · 5 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Dec 2018 · 6 months · monthly snapshot~Dec 2018 – ~Mar 2019 · 3 months · monthly snapshot~Mar 2019 – ~Jul 2019 · 4 months · monthly snapshot~Jul 2019 – ~Dec 2019 · 5 months · monthly snapshot~Dec 2019 – ~Mar 2020 · 3 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Aug 2020 · 4 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Dec 2021 · 8 months · monthly snapshot~Dec 2021 – ~Dec 2022 · 12 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Jul 2024 · 18 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 21 months · monthly snapshot

Change History

21 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  3. Jan 2023 — Jul 2024 [monthly]

    Completed PHASE2

  4. Dec 2022 — Jan 2023 [monthly]

    Completed PHASE2

  5. Dec 2021 — Dec 2022 [monthly]

    Completed PHASE2

▶ Show 16 earlier versions

  1. Apr 2021 — Dec 2021 [monthly]

    Completed PHASE2

  2. Jan 2021 — Apr 2021 [monthly]

    Completed PHASE2

  3. Aug 2020 — Jan 2021 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  4. Apr 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2

  5. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  6. Dec 2019 — Mar 2020 [monthly]

    Recruiting PHASE2

  7. Jul 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

    Phase: NA → PHASE2

  8. Mar 2019 — Jul 2019 [monthly]

    Recruiting NA

  9. Dec 2018 — Mar 2019 [monthly]

    Recruiting NA

  10. Jun 2018 — Dec 2018 [monthly]

    Recruiting NA

  11. Feb 2018 — Jun 2018 [monthly]

    Recruiting NA

  12. Sep 2017 — Feb 2018 [monthly]

    Recruiting NA

  13. Aug 2017 — Sep 2017 [monthly]

    Recruiting NA

  14. Mar 2017 — Aug 2017 [monthly]

    Recruiting NA

  15. Feb 2017 — Mar 2017 [monthly]

    Recruiting NA

  16. Jan 2017 — Feb 2017 [monthly]

    Recruiting NA

    First recorded

Sep 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
  • University of Washington
Data source: University of Washington

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations