deltatrials
Terminated PHASE1 INTERVENTIONAL 1-arm NCT02757391

CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors

Pilot Study of Feasibility and Safety of Personalized Autologous CD8+ T Cell Therapy Plus Anti-PD1 Antibody in Advanced Solid Malignancies

Sponsor: M.D. Anderson Cancer Center

Conditions Colorectal Adenocarcinoma Metastatic Cholangiocarcinoma Metastatic Colorectal Carcinoma Metastatic Digestive System Carcinoma Metastatic Esophageal Carcinoma Metastatic Gastric Carcinoma Metastatic Pancreatic Adenocarcinoma Stage IV Colorectal Cancer AJCC v7 Stage IV Esophageal Cancer AJCC v7 Stage IV Gastric Cancer AJCC v7 Stage IV Pancreatic Cancer AJCC v6 and v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7
Interventions Adoptive Immunotherapy Aldesleukin Cyclophosphamide Laboratory Biomarker Analysis Pembrolizumab
Updated 19 times since 2017 Last updated: Oct 28, 2020 Started: Aug 9, 2019 Primary completion: Oct 2, 2020 Completion: Oct 2, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention.

Other terminated trials from M.D. Anderson Cancer Center

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A PHASE1 clinical study on Colorectal Adenocarcinoma and Metastatic Cholangiocarcinoma, this trial is terminated or withdrawn. The trial is conducted by M.D. Anderson Cancer Center and has accumulated 19 data snapshots since 2019. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2018 · 13 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~May 2019 · 5 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Aug 2020 · 8 months · monthly snapshot~Aug 2020 – ~Nov 2020 · 3 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 24 months · monthly snapshot

Change History

19 versions recorded

  1. Sep 2024 — Present [monthly]

    Terminated PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  3. Dec 2021 — Jul 2024 [monthly]

    Terminated PHASE1

  4. Jan 2021 — Dec 2021 [monthly]

    Terminated PHASE1

  5. Nov 2020 — Jan 2021 [monthly]

    Terminated PHASE1

    Status: Active Not Recruiting → Terminated

▶ Show 14 earlier versions

  1. Aug 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE1

  2. Dec 2019 — Aug 2020 [monthly]

    Active Not Recruiting PHASE1

    Status: Enrolling By Invitation → Active Not Recruiting

  3. Oct 2019 — Dec 2019 [monthly]

    Enrolling By Invitation PHASE1

    Status: Recruiting → Enrolling By Invitation

  4. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  5. Jul 2019 — Sep 2019 [monthly]

    Not Yet Recruiting PHASE1

  6. Jun 2019 — Jul 2019 [monthly]

    Not Yet Recruiting PHASE1

  7. May 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE1

  8. Dec 2018 — May 2019 [monthly]

    Not Yet Recruiting PHASE1

  9. Nov 2018 — Dec 2018 [monthly]

    Not Yet Recruiting PHASE1

  10. Sep 2018 — Nov 2018 [monthly]

    Not Yet Recruiting PHASE1

  11. Jun 2018 — Sep 2018 [monthly]

    Not Yet Recruiting PHASE1

  12. May 2017 — Jun 2018 [monthly]

    Not Yet Recruiting PHASE1

  13. Feb 2017 — May 2017 [monthly]

    Not Yet Recruiting PHASE1

  14. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations