deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT02758717

Nivolumab and Brentuximab Vedotin in Treating Older Patients With Untreated Hodgkin Lymphoma

Phase II, Multi-Center Trial of Nivolumab and Brentuximab Vedotin in Patients With Untreated Hodgkin Lymphoma Over the Age of 60 Years or Unable to Receive Standard Adriamycin, Bleomycin, Vinblastine, and Dacarbazine (ABVD) Chemotherapy

Sponsor: Academic and Community Cancer Research United

Conditions Ann Arbor Stage IB Hodgkin Lymphoma Ann Arbor Stage II Hodgkin Lymphoma Ann Arbor Stage IIA Hodgkin Lymphoma Ann Arbor Stage IIB Hodgkin Lymphoma Ann Arbor Stage III Hodgkin Lymphoma Ann Arbor Stage IIIA Hodgkin Lymphoma Ann Arbor Stage IIIB Hodgkin Lymphoma Ann Arbor Stage IV Hodgkin Lymphoma Ann Arbor Stage IVA Hodgkin Lymphoma Ann Arbor Stage IVB Hodgkin Lymphoma Classic Hodgkin Lymphoma
Interventions Brentuximab Vedotin Nivolumab
Updated 26 times since 2017 Last updated: Aug 27, 2025 Started: May 13, 2016 Primary completion: Aug 13, 2019 Completion: Sep 13, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Ann Arbor Stage IB Hodgkin Lymphoma and Ann Arbor Stage II Hodgkin Lymphoma, this trial is ongoing. The trial is conducted by Academic and Community Cancer Research United and has accumulated 26 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Oct 2017 · 5 months · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Mar 2018 · 3 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Feb 2019 · 6 months · monthly snapshot~Feb 2019 – ~Dec 2019 · 10 months · monthly snapshot~Dec 2019 – ~Oct 2020 · 10 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Feb 2022 · 13 months · monthly snapshot~Feb 2022 – ~Sep 2022 · 7 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Nov 2023 · 10 months · monthly snapshot~Nov 2023 – ~Mar 2024 · 4 months · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – present · 11 months · monthly snapshot

Change History

26 versions recorded

  1. Oct 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2024 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 21 earlier versions

  1. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  2. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Nov 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Jan 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  7. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE2

  8. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

  9. Feb 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  10. Jan 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE2

  11. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  12. Dec 2019 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  13. Feb 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  14. Aug 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  15. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  16. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  17. Dec 2017 — Mar 2018 [monthly]

    Recruiting PHASE2

  18. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  19. May 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  20. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE2

  21. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

May 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Academic and Community Cancer Research United
  • National Cancer Institute (NCI)
Data source: Academic and Community Cancer Research United

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations