deltatrials
Completed PHASE4 INTERVENTIONAL 2-arm NCT02768298

Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction.

A Randomized, Double-blind, Active-controlled Study to Assess the Effect of LCZ696 Compared With Enalapril to Improve Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF).

Sponsor: Novartis Pharmaceuticals

Conditions Chronic Heart Failure With Reduced Ejection Fraction
Interventions Enalapril LCZ696 Placebo matching LCZ696 Placebo matching enalapril
Updated 21 times since 2017 Last updated: Oct 7, 2021 Started: Jul 12, 2016 Primary completion: Nov 25, 2019 Completion: Nov 25, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Chronic Heart Failure With Reduced Ejection Fraction and is currently completed. Novartis Pharmaceuticals leads this study, which shows 21 recorded versions since 2016 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

~Jan 2017 – ~Aug 2017 · 7 months · monthly snapshot~Aug 2017 – ~Dec 2017 · 4 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jan 2020 · 9 months · monthly snapshot~Jan 2020 – ~May 2020 · 4 months · monthly snapshot~May 2020 – ~Nov 2020 · 6 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Nov 2021 · 10 months · monthly snapshot~Nov 2021 – ~Jul 2024 · 32 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

21 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE4

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE4

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE4

  4. Nov 2021 — Jul 2024 [monthly]

    Completed PHASE4

  5. Jan 2021 — Nov 2021 [monthly]

    Completed PHASE4

▶ Show 16 earlier versions

  1. Nov 2020 — Jan 2021 [monthly]

    Completed PHASE4

  2. May 2020 — Nov 2020 [monthly]

    Completed PHASE4

    Status: Active Not Recruiting → Completed

  3. Jan 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

  4. Apr 2019 — Jan 2020 [monthly]

    Recruiting PHASE4

  5. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE4

  6. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE4

  7. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE4

  8. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE4

  9. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE4

  10. Sep 2018 — Nov 2018 [monthly]

    Recruiting PHASE4

  11. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE4

  12. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE4

  13. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE4

  14. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE4

  15. Aug 2017 — Dec 2017 [monthly]

    Recruiting PHASE4

  16. Jan 2017 — Aug 2017 [monthly]

    Recruiting PHASE4

    First recorded

Jul 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis Pharmaceuticals
Data source: Novartis

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Berlin, Germany , Bonn, Germany , Cologne, Germany , Dresden, Germany , Erfurt, Germany , Frankfurt, Germany , Freiburg im Breisgau, Germany , Göttingen, Germany , Hamburg, Germany , Heidelberg, Germany and 18 more locations