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Completed PHASE2 INTERVENTIONAL 2-arm NCT02799745

A Randomized Study of Enzalutamide in Patients With Localized Prostate Cancer Undergoing Active Surveillance (ENACT)

A Randomized Study of Enzalutamide in Patients With Localized Prostate Cancer Undergoing Active Surveillance (ENACT)

Sponsor: Astellas Pharma Global Development, Inc.

Conditions Prostate Cancer
Interventions Active Surveillance Enzalutamide
Updated 33 times since 2017 Last updated: Nov 19, 2024 Started: Jun 9, 2016 Primary completion: Aug 28, 2020 Completion: Aug 28, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Prostate Cancer, this trial is completed. The trial is conducted by Astellas Pharma Global Development, Inc. and has accumulated 33 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~Jun 2017 · 2 months · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Feb 2018 · 2 months · monthly snapshot~Feb 2018 – ~Apr 2018 · 59 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~May 2019 · 5 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Sep 2019 · 3 months · monthly snapshot~Sep 2019 – ~Dec 2019 · 3 months · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Sep 2025 · 8 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

33 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Jan 2025 — Sep 2025 [monthly]

    Completed PHASE2

  3. Sep 2024 — Jan 2025 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Dec 2021 — Jul 2024 [monthly]

    Completed PHASE2

▶ Show 28 earlier versions

  1. Jan 2021 — Dec 2021 [monthly]

    Completed PHASE2

  2. Nov 2020 — Jan 2021 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  3. Sep 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2

  4. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE2

  5. Jun 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2

  6. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE2

  7. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE2

  8. Feb 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE2

  9. Dec 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE2

  10. Sep 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE2

  11. Jun 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE2

  12. May 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE2

  13. Dec 2018 — May 2019 [monthly]

    Active Not Recruiting PHASE2

  14. Nov 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE2

  15. Oct 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  16. Jun 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  17. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  18. Feb 2018 — Apr 2018 [monthly]

    Recruiting PHASE2

  19. Dec 2017 — Feb 2018 [monthly]

    Recruiting PHASE2

  20. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  21. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE2

  22. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  23. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE2

  24. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  25. Jun 2017 — Jul 2017 [monthly]

    Recruiting PHASE2

  26. Apr 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  27. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE2

  28. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Jun 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Astellas Pharma Global Development, Inc.
  • Medivation LLC, a wholly owned subsidiary of Pfizer Inc.
Data source: Astellas Pharma Inc

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Abbotsford, Canada , Aurora, United States , Bala-Cynwyd, United States , Birmingham, United States , Boston, United States , Bradenton, United States , Brooklyn, United States , Carmel, United States , Cheektowaga, United States , Chicago, United States and 37 more locations