deltatrials
Completed PHASE4 INTERVENTIONAL 3-arm NCT02810704

Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement (PEPPER)

Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement: Balancing Safety and Effectiveness

Sponsor: Brigham and Women's Hospital

Updated 19 times since 2017 Last updated: Nov 20, 2025 Started: Dec 31, 2016 Primary completion: Sep 30, 2025 Completion: Sep 30, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE4 clinical study on Pulmonary Embolism and Venous Thrombosis, this trial is completed. The trial is conducted by Brigham and Women's Hospital and has accumulated 19 data snapshots since 2016. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Feb 2018 · 9 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshot~Mar 2019 – ~Jun 2019 · 3 months · monthly snapshot~Jun 2019 – ~Sep 2019 · 3 months · monthly snapshot~Sep 2019 – ~May 2020 · 8 months · monthly snapshot~May 2020 – ~Oct 2020 · 5 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Dec 2022 · 15 months · monthly snapshot~Dec 2022 – ~Dec 2023 · 12 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Dec 2025 · 10 months · monthly snapshot~Dec 2025 – present · 9 months · monthly snapshot

Change History

19 versions recorded
  1. Dec 2025 — Present [monthly]

    Completed PHASE4

    Status: Active Not RecruitingCompleted

  2. Feb 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE4

    Status: RecruitingActive Not Recruiting

  3. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE4

  4. Sep 2024 — Jan 2025 [monthly]

    Recruiting PHASE4

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE4

Show 14 earlier versions
  1. Dec 2023 — Jul 2024 [monthly]

    Recruiting PHASE4

  2. Dec 2022 — Dec 2023 [monthly]

    Recruiting PHASE4

  3. Sep 2021 — Dec 2022 [monthly]

    Recruiting PHASE4

  4. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE4

  5. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE4

    Status: Active Not RecruitingRecruiting

  6. May 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE4

    Status: RecruitingActive Not Recruiting

  7. Sep 2019 — May 2020 [monthly]

    Recruiting PHASE4

  8. Jun 2019 — Sep 2019 [monthly]

    Recruiting PHASE4

  9. Mar 2019 — Jun 2019 [monthly]

    Recruiting PHASE4

  10. Jun 2018 — Mar 2019 [monthly]

    Recruiting PHASE4

  11. Feb 2018 — Jun 2018 [monthly]

    Recruiting PHASE4

  12. May 2017 — Feb 2018 [monthly]

    Recruiting PHASE4

    Status: Not Yet RecruitingRecruiting

  13. Feb 2017 — May 2017 [monthly]

    Not Yet Recruiting PHASE4

  14. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Dec 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Brigham and Women's Hospital
  • Dartmouth-Hitchcock Medical Center
  • Medical University of South Carolina
  • Northwestern University
  • Patient-Centered Outcomes Research Institute
  • University of Maryland, Baltimore
Data source: Dartmouth-Hitchcock Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .