Completed PHASE2 INTERVENTIONAL 2-arm NCT02811055

Pilot Study of Aprepitant Effect on Aldosterone Secretion in Diabetic Patient (Diabetes Mellitus) With Hypertension Associated With Low Renin (APHOS-02)

Sponsor: University Hospital, Rouen

Interventions Administration of Aprepitant Administration of placebo Blood Pressure Measurement Blood sampling electrocardiogram orthostatic test

Updated 9 times since 2017 Last updated: Feb 4, 2026 Started: Jul 13, 2017 Primary completion: Dec 5, 2020 Completion: Dec 5, 2020

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Hypertension and Type 2 Diabetes, this trial is completed. The trial is conducted by University Hospital, Rouen and has accumulated 9 data snapshots since 2017. Cardiovascular trials of this type often inform treatment guidelines for long-term patient management.

Status Flow

Change History

9 versions recorded

Feb 2026 — Present [monthly]

Completed PHASE2

Status: Unknown → Completed
Sep 2024 — Feb 2026 [monthly]

Unknown PHASE2
Jul 2024 — Sep 2024 [monthly]

Unknown PHASE2

Status: Unknown Status → Unknown
Jan 2021 — Jul 2024 [monthly]

Unknown Status PHASE2
Sep 2019 — Jan 2021 [monthly]

Unknown Status PHASE2

Status: Recruiting → Unknown Status

▶ Show 4 earlier versions

Jun 2018 — Sep 2019 [monthly]

Recruiting PHASE2
Sep 2017 — Jun 2018 [monthly]

Recruiting PHASE2

Status: Not Yet Recruiting → Recruiting
Aug 2017 — Sep 2017 [monthly]

Not Yet Recruiting PHASE2
Jan 2017 — Aug 2017 [monthly]

Not Yet Recruiting PHASE2

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

University Hospital, Rouen

Data source: University Hospital, Rouen

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Rouen, France