deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 5-arm NCT02888743

Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer

A Phase 2 Study of MEDI4736 (Durvalumab) and Tremelimumab Alone or in Combination With High or Low-Dose Radiation in Metastatic Colorectal and NSCLC

Sponsor: National Cancer Institute (NCI)

Conditions Metastatic Colorectal Carcinoma Metastatic Lung Non-Small Cell Carcinoma Stage IV Colorectal Cancer AJCC v7 Stage IV Lung Non-Small Cell Cancer AJCC v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7
Interventions Durvalumab Radiation Therapy Tremelimumab
Updated 58 times since 2017 Last updated: Mar 12, 2026 Started: Aug 14, 2017 Primary completion: Dec 31, 2023 Completion: Jan 2, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Metastatic Colorectal Carcinoma and Metastatic Lung Non-Small Cell Carcinoma, this trial is ongoing. The trial is conducted by National Cancer Institute (NCI) and has accumulated 58 data snapshots since 2017. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Feb 2018 · 2 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Dec 2018 · 3 months · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Nov 2020 · 4 months · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Sep 2021 · 7 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Sep 2023 · 3 months · monthly snapshot~Sep 2023 – ~Nov 2023 · 2 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Aug 2025 · 5 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Mar 2026 · 6 months · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

58 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2025 — Mar 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Mar 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 53 earlier versions

  1. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Feb 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

  7. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE2

  8. Sep 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  9. Jun 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE2

  10. Apr 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

  11. Feb 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

  12. Dec 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

  13. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

  14. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  15. May 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  16. Feb 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE2

  17. Sep 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE2

  18. Feb 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  19. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2

  20. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  21. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE2

  22. Jul 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2

  23. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE2

  24. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE2

  25. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE2

  26. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE2

  27. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE2

  28. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE2

  29. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE2

  30. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE2

  31. Oct 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE2

  32. Sep 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE2

  33. Jul 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE2

  34. May 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  35. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  36. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  37. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  38. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  39. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  40. Sep 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  41. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  42. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  43. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  44. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  45. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

  46. Dec 2017 — Feb 2018 [monthly]

    Recruiting PHASE2

  47. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  48. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  49. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE2

  50. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  51. Jun 2017 — Jul 2017 [monthly]

    Not Yet Recruiting PHASE2

  52. Feb 2017 — Jun 2017 [monthly]

    Not Yet Recruiting PHASE2

  53. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Baltimore, United States , Boston, United States , Chapel Hill, United States , Charlottesville, United States , City of Saint Peters, United States , Cleveland, United States , Columbus, United States , Creve Coeur, United States , Detroit, United States and 23 more locations