deltatrials
Completed PHASE4 INTERVENTIONAL 2-arm NCT02891850

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy (REPLACE)

A Prospective, Randomized, International, Multicenter, Double-arm, Controlled, Open-label Study of Riociguat in Patients With Pulmonary Arterial Hypertension (PAH) Who Are on a Stable Dose of Phosphodiesterase-5 Inhibitors (PDE-5i) With or Without Endothelin Receptor Antagonist (ERA), But Not at Treatment Goal

Sponsor: Bayer

Conditions Pulmonary Arterial Hypertension
Interventions Riociguat (Adempas, BAY63-2521) Sildenafil Tadalafil
Updated 38 times since 2017 Last updated: Feb 3, 2021 Started: Jan 11, 2017 Primary completion: Jan 29, 2020 Completion: Mar 3, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Pulmonary Arterial Hypertension and is currently completed. Bayer leads this study, which shows 38 recorded versions since 2017 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Nov 2017 · 3 months · monthly snapshot~Nov 2017 – ~May 2018 · 6 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jan 2021 · 9 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Jul 2024 · 40 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

38 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE4

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE4

  3. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE4

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE4

  5. Mar 2021 — Jul 2024 [monthly]

    Completed PHASE4

▶ Show 33 earlier versions

  1. Feb 2021 — Mar 2021 [monthly]

    Completed PHASE4

  2. Jan 2021 — Feb 2021 [monthly]

    Completed PHASE4

  3. Apr 2020 — Jan 2021 [monthly]

    Completed PHASE4

    Status: Active Not Recruiting → Completed

  4. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE4

  5. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE4

  6. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE4

  7. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE4

  8. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

  9. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE4

  10. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE4

  11. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE4

  12. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE4

  13. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE4

  14. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE4

  15. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE4

  16. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE4

  17. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE4

  18. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE4

  19. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE4

  20. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE4

  21. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE4

  22. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE4

  23. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE4

  24. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE4

  25. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE4

  26. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE4

  27. Nov 2017 — May 2018 [monthly]

    Recruiting PHASE4

  28. Aug 2017 — Nov 2017 [monthly]

    Recruiting PHASE4

  29. Jun 2017 — Aug 2017 [monthly]

    Recruiting PHASE4

  30. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE4

  31. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE4

  32. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE4

  33. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE4

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bayer
Data source: Bayer

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aarhus N, Denmark , Almada, Portugal , Amsterdam, Netherlands , Ankara, Turkey (Türkiye) , Barcelona, Spain , Belo Horizonte, Brazil , Berlin, Germany , Blumenal, Brazil , Bunkyo-ku, Japan , Chaïdári, Greece and 60 more locations