deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT02905591

A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC (XACT-LUNG)

A Phase 2 Trial of Pharmacological Ascorbate With Concurrent Chemotherapy and Radiation Therapy for Non-small Cell Lung Cancer

Sponsor: Holden Comprehensive Cancer Center

Conditions Carcinoma, Non-Small-Cell Lung NSCLC Non-Small Cell Lung Cancer Non-Small-Cell Lung Carcinoma Nonsmall Cell Lung Cancer
Interventions Ascorbic Acid Carboplatin Paclitaxel Radiation Therapy
Updated 23 times since 2017 Last updated: Dec 23, 2025 Started: Nov 16, 2018 Primary completion: Jul 17, 2025 Completion: Dec 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Carcinoma, Non-Small-Cell Lung and NSCLC, this trial is ongoing. The trial is conducted by Holden Comprehensive Cancer Center and has accumulated 23 data snapshots since 2018. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~May 2018 · 14 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~May 2020 · 16 months · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Oct 2020 · 3 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Sep 2022 · 11 months · monthly snapshot~Sep 2022 – ~Sep 2023 · 12 months · monthly snapshot~Sep 2023 – ~Jul 2024 · 10 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Feb 2025 · 2 months · monthly snapshot~Feb 2025 – ~Sep 2025 · 7 months · monthly snapshot~Sep 2025 – ~Jan 2026 · 4 months · monthly snapshot~Jan 2026 – present · 6 months · monthly snapshot

Change History

23 versions recorded

  1. Jan 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  3. Feb 2025 — Sep 2025 [monthly]

    Recruiting PHASE2

  4. Dec 2024 — Feb 2025 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  5. Nov 2024 — Dec 2024 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

▶ Show 18 earlier versions

  1. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE2

  2. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  3. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

  4. Sep 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

  5. Sep 2022 — Sep 2023 [monthly]

    Recruiting PHASE2

  6. Oct 2021 — Sep 2022 [monthly]

    Recruiting PHASE2

  7. Jan 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  8. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  9. Jul 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  10. May 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  11. Jan 2019 — May 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  12. Nov 2018 — Jan 2019 [monthly]

    Not Yet Recruiting PHASE2

  13. Oct 2018 — Nov 2018 [monthly]

    Not Yet Recruiting PHASE2

  14. Jun 2018 — Oct 2018 [monthly]

    Not Yet Recruiting PHASE2

  15. May 2018 — Jun 2018 [monthly]

    Not Yet Recruiting PHASE2

  16. Mar 2017 — May 2018 [monthly]

    Not Yet Recruiting PHASE2

  17. Feb 2017 — Mar 2017 [monthly]

    Not Yet Recruiting PHASE2

  18. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Holden Comprehensive Cancer Center
  • Joseph J. Cullen, MD, FACS
  • National Cancer Institute (NCI)
  • National Institutes of Health (NIH)
Data source: University of Iowa

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations