deltatrials
Completed PHASE1 INTERVENTIONAL 4-arm NCT02922764

A Study of RGX-104 in Patients With Advanced Lung & Endometrial Cancer

A Phase 1 Study of RGX-104, a Small Molecule LXR Agonist, as a Single Agent and as Combination Therapy in Patients With Advanced Solid Malignancies and Expansion in Select Malignancies

Sponsor: Inspirna, Inc.

Conditions Endometrial Cancer Endometrial Cancer Recurrent Lung Cancer Lung Cancer Recurrent Non-small Cell Carcinoma Non-small Cell Lung Cancer Metastatic
Interventions Carboplatin Docetaxel Ipilimumab Pembrolizumab Pemetrexed RGX-104
Updated 27 times since 2017 Last updated: Mar 24, 2025 Started: Nov 1, 2016 Primary completion: Jan 22, 2025 Completion: Jan 22, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02922764, this PHASE1 trial focuses on Endometrial Cancer and Endometrial Cancer Recurrent and remains completed. Sponsored by Inspirna, Inc., it has been updated 27 times since 2016, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Oct 2017 · 5 months · monthly snapshot~Oct 2017 – ~Feb 2018 · 4 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Apr 2019 · 10 months · monthly snapshot~Apr 2019 – ~Oct 2019 · 6 months · monthly snapshot~Oct 2019 – ~Apr 2020 · 6 months · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Nov 2021 · 8 months · monthly snapshot~Nov 2021 – ~Sep 2022 · 10 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Sep 2023 · 7 months · monthly snapshot~Sep 2023 – ~Dec 2023 · 3 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Apr 2025 · 5 months · monthly snapshot~Apr 2025 – ~Sep 2025 · 5 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1

  2. Apr 2025 — Sep 2025 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  3. Nov 2024 — Apr 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 22 earlier versions

  1. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  2. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE1

  3. Dec 2023 — Jul 2024 [monthly]

    Recruiting PHASE1

  4. Sep 2023 — Dec 2023 [monthly]

    Recruiting PHASE1

  5. Feb 2023 — Sep 2023 [monthly]

    Recruiting PHASE1

  6. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE1

  7. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  8. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  9. Nov 2021 — Sep 2022 [monthly]

    Recruiting PHASE1

  10. Mar 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  11. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  12. Sep 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  13. Apr 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  14. Oct 2019 — Apr 2020 [monthly]

    Recruiting PHASE1

  15. Apr 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  16. Jun 2018 — Apr 2019 [monthly]

    Recruiting PHASE1

  17. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  18. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE1

  19. Oct 2017 — Feb 2018 [monthly]

    Recruiting PHASE1

  20. May 2017 — Oct 2017 [monthly]

    Recruiting PHASE1

  21. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE1

  22. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Nov 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Inspirna, Inc.
Data source: Inspirna, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aurora, United States , Columbia, United States , Denver, United States , Fairfax, United States , Lake Mary, United States , Lebanon, United States , Los Angeles, United States , Louisville, United States , Nashville, United States , New Brunswick, United States and 9 more locations