deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 2-arm NCT02923115

Study to Assess the Safety, Pharmacokinetics/Dynamics of DS-1040b in Subjects With Acute Submassive Pulmonary Embolism

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Single Ascending Dose Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of DS-1040b When Added to Standard of Care Anticoagulation Therapy in Subjects With Acute Submassive Pulmonary Embolism

Sponsor: Daiichi Sankyo

Conditions Pulmonary Embolism Thrombotic Disease
Interventions DS-1040b Enoxaparin Placebo
Updated 31 times since 2017 Last updated: Apr 18, 2023 Started: Jun 23, 2016 Primary completion: Aug 5, 2019 Completion: Aug 5, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02923115, this PHASE1/PHASE2 trial focuses on Pulmonary Embolism and Thrombotic Disease and remains completed. Sponsored by Daiichi Sankyo, it has been updated 31 times since 2016, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jul 2017 · 2 months · monthly snapshot~Jul 2017 – ~Sep 2017 · 2 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Aug 2020 · 11 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~May 2023 · 28 months · monthly snapshot~May 2023 – ~Mar 2024 · 10 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

31 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  4. Mar 2024 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

  5. May 2023 — Mar 2024 [monthly]

    Completed PHASE1_PHASE2

▶ Show 26 earlier versions

  1. Jan 2021 — May 2023 [monthly]

    Completed PHASE1_PHASE2

  2. Aug 2020 — Jan 2021 [monthly]

    Completed PHASE1_PHASE2

  3. Sep 2019 — Aug 2020 [monthly]

    Completed PHASE1_PHASE2

    Status: Recruiting → Completed

  4. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE1_PHASE2

  5. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

  6. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1_PHASE2

  7. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1_PHASE2

  8. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1_PHASE2

  9. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1_PHASE2

  10. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1_PHASE2

  11. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1_PHASE2

  12. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE1_PHASE2

  13. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE1_PHASE2

  14. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE1_PHASE2

  15. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1_PHASE2

  16. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1_PHASE2

  17. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1_PHASE2

  18. Jan 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  19. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE1_PHASE2

  20. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE1_PHASE2

  21. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE1_PHASE2

  22. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE1_PHASE2

  23. Jul 2017 — Sep 2017 [monthly]

    Recruiting PHASE1_PHASE2

  24. May 2017 — Jul 2017 [monthly]

    Recruiting PHASE1_PHASE2

  25. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE1_PHASE2

  26. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Jun 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Daiichi Sankyo
Data source: Daiichi Sankyo

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Alkmaar, Netherlands , Amsterdam, Netherlands , Ancona, Italy , Beverly Hills, United States , Boston, United States , Brest, France , Brussels, Belgium , Butte, United States , Camp Hill, United States , Chicago, United States and 33 more locations