deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 2-arm NCT02959463

Pembrolizumab After Radiation Therapy in Treating Patients With Pleural Malignant Mesothelioma

Phase I Trial of Adjuvant Pembrolizumab After Radiation Therapy for Lung-Intact Malignant Pleural Mesothelioma

Sponsor: M.D. Anderson Cancer Center

Conditions Pleural Malignant Mesothelioma
Interventions Laboratory Biomarker Analysis Palliative Radiation Therapy Pembrolizumab Radiation Therapy
Updated 22 times since 2017 Last updated: Feb 20, 2026 Started: May 1, 2017 Primary completion: Nov 15, 2024 Completion: Dec 31, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02959463, this PHASE1 trial focuses on Pleural Malignant Mesothelioma and remains ongoing. Sponsored by M.D. Anderson Cancer Center, it has been updated 22 times since 2017, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Jun 2018 · 12 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Apr 2019 · 8 months · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Jan 2021 · 19 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Mar 2022 · 5 months · monthly snapshot~Mar 2022 – ~Jun 2022 · 3 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Sep 2023 · 7 months · monthly snapshot~Sep 2023 – ~Mar 2024 · 6 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Sep 2025 · 6 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – ~Mar 2026 · 3 months · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

22 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Dec 2025 — Mar 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Mar 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 17 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Mar 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Feb 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  6. Jun 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  7. Mar 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

    Status: Unknown Status → Recruiting

  8. Oct 2021 — Mar 2022 [monthly]

    Unknown Status PHASE1

    Status: Recruiting → Unknown Status

  9. Jan 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  10. Jun 2019 — Jan 2021 [monthly]

    Recruiting PHASE1

  11. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  12. Aug 2018 — Apr 2019 [monthly]

    Recruiting PHASE1

  13. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  14. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

  15. Jun 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  16. Feb 2017 — Jun 2017 [monthly]

    Not Yet Recruiting PHASE1

  17. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations