deltatrials
Terminated PHASE3 INTERVENTIONAL 4-arm NCT02967692

A Study of the Anti-PD1 Antibody PDR001, in Combination With Dabrafenib and Trametinib in Advanced Melanoma (COMBI-i)

A Randomized, Double-blind, Placebo-controlled, Phase III Study Comparing the Combination of PDR001, Dabrafenib and Trametinib Versus Placebo, Dabrafenib and Trametinib in Previously Untreated Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma

Sponsor: Novartis Pharmaceuticals

Conditions Melanoma
Interventions Dabrafenib Placebo Spartalizumab Trametinib
Updated 62 times since 2017 Last updated: Sep 1, 2025 Started: Feb 17, 2017 Primary completion: Aug 11, 2020 Completion: Aug 21, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Sponsor decision

Other terminated trials from Novartis Pharmaceuticals

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Other Melanoma trials with similar outcome

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Listed as NCT02967692, this PHASE3 trial focuses on Melanoma and remains terminated or withdrawn. Sponsored by Novartis Pharmaceuticals, it has been updated 62 times since 2017, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jul 2017 · 2 months · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Feb 2018 · 2 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~May 2018 · 30 days · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~Sep 2022 · 5 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~May 2023 · 6 months · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Nov 2023 · 2 months · monthly snapshot~Nov 2023 – ~Jan 2024 · 2 months · monthly snapshot~Jan 2024 – ~Mar 2024 · 2 months · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~May 2025 · 3 months · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – present · 9 months · monthly snapshot

Change History

62 versions recorded

  1. Oct 2025 — Present [monthly]

    Terminated PHASE3

  2. Sep 2025 — Oct 2025 [monthly]

    Terminated PHASE3

  3. May 2025 — Sep 2025 [monthly]

    Terminated PHASE3

    Status: Completed → Terminated

  4. Feb 2025 — May 2025 [monthly]

    Completed PHASE3

  5. Jan 2025 — Feb 2025 [monthly]

    Completed PHASE3

▶ Show 57 earlier versions

  1. Nov 2024 — Jan 2025 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  2. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE3

  5. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  6. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE3

  7. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Jan 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Nov 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE3

  10. Sep 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  11. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  12. May 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  13. Nov 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  14. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  15. Apr 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  16. Feb 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  17. Sep 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  18. May 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  19. Jan 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE3

  20. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  21. Sep 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  22. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  23. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  24. May 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  25. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  26. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  27. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  28. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE3

  29. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  30. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  31. Sep 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  32. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  33. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  34. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

    Status: Active Not Recruiting → Recruiting

  35. May 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  36. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  37. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

    Status: Active Not Recruiting → Recruiting

  38. Feb 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  39. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  40. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  41. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  42. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  43. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  44. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  45. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  46. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  47. Apr 2018 — May 2018 [monthly]

    Recruiting PHASE3

  48. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE3

  49. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

  50. Dec 2017 — Feb 2018 [monthly]

    Recruiting PHASE3

  51. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  52. Aug 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  53. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

  54. May 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

  55. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  56. Feb 2017 — Apr 2017 [monthly]

    Not Yet Recruiting PHASE3

  57. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis Pharmaceuticals
Data source: Novartis

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

A Coruña, Spain , Aarau, Switzerland , Aarhus N, Denmark , Amersfroort, Netherlands , Amiens, France , Athens, Greece , Badalona, Spain , Bangkok, Thailand , Barcelona, Spain , Bari, Italy and 156 more locations