deltatrials
Active Not Recruiting PHASE2 NCT02968212

Clofazimine in the Treatment of Pulmonary Mycobacterium Avium Complex (MAC)

Phase 2 Study of Clofazimine for the Treatment of Pulmonary Mycobacterium Avium Disease

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Conditions Mycobacterium Avium Complex
Interventions Clofazimine sugar pill
Updated 34 times since 2017 Last updated: Sep 3, 2025 Started: Apr 11, 2017 Primary completion: Aug 29, 2025 Completion: Mar 31, 2026

This PHASE2 trial investigates Mycobacterium Avium Complex and is currently ongoing. National Heart, Lung, and Blood Institute (NHLBI) leads this study, which shows 34 recorded versions since 2017 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Aug 2017 · 6 months · monthly snapshot~Aug 2017 – ~Jun 2018 · 10 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Oct 2018 · 3 months · monthly snapshot~Oct 2018 – ~Jan 2019 · 3 months · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Jan 2020 · 3 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Jul 2020 · 5 months · monthly snapshot~Jul 2020 – ~Oct 2020 · 3 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Apr 2023 · 3 months · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Nov 2023 · 6 months · monthly snapshot~Nov 2023 – ~Feb 2024 · 3 months · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Oct 2025 · 9 months · monthly snapshot~Oct 2025 – present · 6 months · monthly snapshot

Change History

34 versions recorded

  1. Oct 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Jan 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  3. Sep 2024 — Jan 2025 [monthly]

    Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

▶ Show 29 earlier versions

  1. Feb 2024 — Apr 2024 [monthly]

    Recruiting PHASE2

  2. Nov 2023 — Feb 2024 [monthly]

    Recruiting PHASE2

  3. May 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  4. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  5. Jan 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  6. Sep 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  7. Jun 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  8. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  9. Feb 2022 — May 2022 [monthly]

    Recruiting PHASE2

  10. Sep 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  11. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  12. Jan 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  13. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  14. Jul 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  15. Feb 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  16. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  17. Oct 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  18. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  19. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  20. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  21. Apr 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  22. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  23. Jan 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  24. Oct 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  25. Jul 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  26. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  27. Aug 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  28. Feb 2017 — Aug 2017 [monthly]

    Not Yet Recruiting PHASE2

  29. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Heart, Lung, and Blood Institute (NHLBI)
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • National Jewish Health
  • Oregon Health and Science University
  • Temple University
  • The University of Texas Health Science Center at Tyler
  • University of Chicago
  • University of South Florida
Data source: Oregon Health and Science University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations