High-Intensity vs Low-Intensity NPPV in Patients With an AECOPD: The HAPPEN Trial
Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease The HAPPEN Randomized Clinical Trial
Sponsor: Beijing Chao Yang Hospital
Terminated
The trial has been terminated by the DSMB and the trial steering committee, based on the interim analysis results and the impracticality of continuing the trial in the context of the coronavirus disease 2019 (COVID-19) pandemic.
This NA trial investigates Acute Exacerbation of Chronic Obstructive Pulmonary Disease and is currently terminated or withdrawn. Beijing Chao Yang Hospital leads this study, which shows 11 recorded versions since 2019 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.
Status Flow
Change History
11 versions recorded-
Sep 2025 — Present [monthly]
Terminated NA
-
Sep 2024 — Sep 2025 [monthly]
Terminated NA
-
Jul 2024 — Sep 2024 [monthly]
Terminated NA
-
Mar 2024 — Jul 2024 [monthly]
Terminated NA
Status: Completed → Terminated
-
Jun 2022 — Mar 2024 [monthly]
Completed NA
Status: Recruiting → Completed
▶ Show 6 earlier versions
-
Sep 2021 — Jun 2022 [monthly]
Recruiting NA
-
Jan 2021 — Sep 2021 [monthly]
Recruiting NA
-
Jun 2019 — Jan 2021 [monthly]
Recruiting NA
-
Jun 2018 — Jun 2019 [monthly]
Recruiting NA
-
May 2018 — Jun 2018 [monthly]
Recruiting NA
Status: Not Yet Recruiting → Recruiting
-
Jan 2017 — May 2018 [monthly]
Not Yet Recruiting NA
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Beijing Chao Yang Hospital
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Bayan Nur, China , Beijing, China , Chongqing, China , Dalian, China , Hangzhou, China , Hebi, China , Huangshi, China , Jiaozuo, China , Kaifeng, China , Luoyang, China and 9 more locations