deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT02990338

Multinational Clinical Study Comparing Isatuximab, Pomalidomide, and Dexamethasone to Pomalidomide and Dexamethasone in Refractory or Relapsed and Refractory Multiple Myeloma Patients (ICARIA-MM)

A Phase 3 Randomized, Open-label, Multicenter Study Comparing Isatuximab (SAR650984) in Combination With Pomalidomide and Low-Dose Dexamethasone Versus Pomalidomide and Low-Dose Dexamethasone in Patients With Refractory or Relapsed and Refractory Multiple Myeloma

Sponsor: Sanofi

Conditions Plasma Cell Myeloma
Interventions Dexamethasone Isatuximab Pomalidomide
Updated 49 times since 2017 Last updated: Jan 16, 2025 Started: Dec 22, 2016 Primary completion: Nov 22, 2018 Completion: Nov 1, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Plasma Cell Myeloma, this trial is completed. The trial is conducted by Sanofi and has accumulated 49 data snapshots since 2016. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Oct 2018 · 3 months · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Jan 2020 · 6 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Nov 2021 · 8 months · monthly snapshot~Nov 2021 – ~Apr 2022 · 5 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Nov 2022 · 6 months · monthly snapshot~Nov 2022 – ~Mar 2023 · 4 months · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jul 2023 · 2 months · monthly snapshot~Jul 2023 – ~Sep 2023 · 2 months · monthly snapshot~Sep 2023 – ~Dec 2023 · 3 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Sep 2025 · 7 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

49 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Feb 2025 — Sep 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Feb 2025 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Dec 2023 — Jul 2024 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

▶ Show 44 earlier versions

  1. Sep 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  2. Jul 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  3. May 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  4. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  5. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  6. Nov 2022 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  7. May 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  8. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE3

  9. Nov 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  10. Mar 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE3

  11. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE3

  12. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  13. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  14. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE3

  15. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  16. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  17. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  18. Apr 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE3

  19. Feb 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  20. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  21. Jul 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

  22. May 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE3

  23. Mar 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE3

  24. Feb 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE3

  25. Jan 2019 — Feb 2019 [monthly]

    Active Not Recruiting PHASE3

  26. Dec 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE3

  27. Nov 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE3

  28. Oct 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE3

  29. Jul 2018 — Oct 2018 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  30. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  31. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  32. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE3

  33. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

  34. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE3

  35. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE3

  36. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  37. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

  38. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  39. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  40. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

  41. Jun 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

  42. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

  43. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE3

  44. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Dec 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Sanofi
Data source: Sanofi

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aalborg, Denmark , Ankara, Turkey (Türkiye) , Antalya, Turkey (Türkiye) , Antwerp, Belgium , Athens, Greece , Auckland, New Zealand , Barcelona, Spain , Bayonne, France , Bologna, Italy , Boston, United States and 84 more locations