deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 4-arm NCT03003533

A Gene Transfer Study for Hemophilia A

Gene-transfer, Open-label, Dose-escalation Study of SPK-8011 [Adeno-associated Viral Vector With B-domain Deleted Human Factor VIII Gene] in Individuals With Hemophilia A

Sponsor: Spark Therapeutics, Inc.

Conditions Hemophilia A
Interventions SPK-8011
Updated 21 times since 2017 Last updated: Dec 5, 2024 Started: Jan 26, 2017 Primary completion: Dec 5, 2023 Completion: Dec 5, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03003533, this PHASE1/PHASE2 trial focuses on Hemophilia A and remains completed. Sponsored by Spark Therapeutics, Inc., it has been updated 21 times since 2017, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Oct 2017 · 8 months · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Jan 2019 · 4 months · monthly snapshot~Jan 2019 – ~Apr 2019 · 3 months · monthly snapshot~Apr 2019 – ~Jun 2020 · 14 months · monthly snapshot~Jun 2020 – ~Dec 2020 · 6 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Mar 2022 · 9 months · monthly snapshot~Mar 2022 – ~Sep 2022 · 6 months · monthly snapshot~Sep 2022 – ~Mar 2023 · 6 months · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~Aug 2023 · 4 months · monthly snapshot~Aug 2023 – ~Feb 2024 · 6 months · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – present · 17 months · monthly snapshot

Change History

21 versions recorded

  1. Feb 2025 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Sep 2024 — Feb 2025 [monthly]

    Completed PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  4. Apr 2024 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

  5. Feb 2024 — Apr 2024 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

▶ Show 16 earlier versions

  1. Aug 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  2. Apr 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  3. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE1_PHASE2

  4. Sep 2022 — Mar 2023 [monthly]

    Recruiting PHASE1_PHASE2

  5. Mar 2022 — Sep 2022 [monthly]

    Recruiting PHASE1_PHASE2

  6. Jun 2021 — Mar 2022 [monthly]

    Recruiting PHASE1_PHASE2

  7. Jan 2021 — Jun 2021 [monthly]

    Recruiting PHASE1_PHASE2

  8. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  9. Jun 2020 — Dec 2020 [monthly]

    Recruiting PHASE1_PHASE2

  10. Apr 2019 — Jun 2020 [monthly]

    Recruiting PHASE1_PHASE2

  11. Jan 2019 — Apr 2019 [monthly]

    Recruiting PHASE1_PHASE2

  12. Sep 2018 — Jan 2019 [monthly]

    Recruiting PHASE1_PHASE2

  13. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE1_PHASE2

  14. Oct 2017 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  15. Feb 2017 — Oct 2017 [monthly]

    Recruiting PHASE1_PHASE2

  16. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Spark Therapeutics, Inc.
Data source: Spark Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Bangkok, Thailand , Boston, United States , Camperdown, Australia , Gainesville, United States , Hamilton, Canada , Hershey, United States , Madison, United States , Melbourne, Australia , New York, United States , Philadelphia, United States and 5 more locations