deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT03008408

A Phase II, Two-Arm Study of Everolimus and Letrozole, +/- Ribociclib (Lee011) in Patients With Advanced or Recurrent Endometrial Carcinoma

A Phase II, Randomized Two-Arm Study of Everolimus and Letrozole, +/- Ribociclib (LEE011) in Patients With Advanced or Recurrent Endometrial Carcinoma

Sponsor: M.D. Anderson Cancer Center

Conditions Recurrent Endometrial Carcinoma Recurrent Endometrial Endometrioid Adenocarcinoma Refractory Endometrial Carcinoma Refractory Endometrial Endometrioid Adenocarcinoma Stage III Uterine Corpus Cancer AJCC v8 Stage IIIA Uterine Corpus Cancer AJCC v8 Stage IIIB Uterine Corpus Cancer AJCC v8 Stage IIIC Uterine Corpus Cancer AJCC v8 Stage IIIC1 Uterine Corpus Cancer AJCC v8 Stage IIIC2 Uterine Corpus Cancer AJCC v8 Stage IV Uterine Corpus Cancer AJCC v8 Stage IVA Uterine Corpus Cancer AJCC v8 Stage IVB Uterine Corpus Cancer AJCC v8
Interventions Everolimus Letrozole Ribociclib
Updated 29 times since 2017 Last updated: Feb 9, 2026 Started: Aug 18, 2017 Primary completion: Aug 31, 2028 Completion: Aug 31, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03008408, this PHASE2 trial focuses on Recurrent Endometrial Carcinoma and Recurrent Endometrial Endometrioid Adenocarcinoma and remains ongoing. Sponsored by M.D. Anderson Cancer Center, it has been updated 29 times since 2017, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jul 2017 · 5 months · monthly snapshot~Jul 2017 – ~Sep 2017 · 2 months · monthly snapshot~Sep 2017 – ~Jun 2018 · 9 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Aug 2020 · 11 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Dec 2020 · 3 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Nov 2021 · 10 months · monthly snapshot~Nov 2021 – ~Sep 2022 · 10 months · monthly snapshot~Sep 2022 – ~Aug 2023 · 11 months · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Jan 2024 · 3 months · monthly snapshot~Jan 2024 – ~Apr 2024 · 3 months · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Jul 2025 · 6 months · monthly snapshot~Jul 2025 – ~Dec 2025 · 5 months · monthly snapshot~Dec 2025 – ~Feb 2026 · 2 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

29 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Dec 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Jul 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jan 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 24 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  2. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  3. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE2

  4. Jan 2024 — Apr 2024 [monthly]

    Recruiting PHASE2

  5. Oct 2023 — Jan 2024 [monthly]

    Recruiting PHASE2

  6. Aug 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  7. Sep 2022 — Aug 2023 [monthly]

    Recruiting PHASE2

  8. Nov 2021 — Sep 2022 [monthly]

    Recruiting PHASE2

  9. Jan 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  10. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  11. Sep 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  12. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  13. Sep 2019 — Aug 2020 [monthly]

    Recruiting PHASE2

  14. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  15. Apr 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  16. Feb 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  17. Dec 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  18. Oct 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  19. Aug 2018 — Oct 2018 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  20. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  21. Sep 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  22. Jul 2017 — Sep 2017 [monthly]

    Not Yet Recruiting PHASE2

  23. Feb 2017 — Jul 2017 [monthly]

    Not Yet Recruiting PHASE2

  24. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations