deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT03018366

Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women

Sponsor: Cedars-Sinai Medical Center

Conditions Cardiovascular Disease (CVD) Endothelial Dysfunction Estrogen Deficiency Functional Hypothalamic Amenorrhea
Interventions 17beta Estradiol Placebo Pill Progesterone Transdermal placebo patch
Updated 15 times since 2017 Last updated: Feb 24, 2025 Started: Jan 1, 2017 Primary completion: Feb 1, 2023 Completion: Feb 1, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Cardiovascular Disease (CVD) and Endothelial Dysfunction and is currently completed. Cedars-Sinai Medical Center leads this study, which shows 15 recorded versions since 2017 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Jan 2019 · 7 months · monthly snapshot~Jan 2019 – ~May 2019 · 4 months · monthly snapshot~May 2019 – ~Jun 2020 · 13 months · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Jun 2022 · 9 months · monthly snapshot~Jun 2022 – ~Jun 2023 · 12 months · monthly snapshot~Jun 2023 – ~Mar 2024 · 9 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – present · 15 months · monthly snapshot

Change History

15 versions recorded

  1. Apr 2025 — Present [monthly]

    Completed PHASE2

  2. Mar 2025 — Apr 2025 [monthly]

    Completed PHASE2

  3. Sep 2024 — Mar 2025 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Mar 2024 — Jul 2024 [monthly]

    Completed PHASE2

▶ Show 10 earlier versions

  1. Jun 2023 — Mar 2024 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  2. Jun 2022 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  3. Sep 2021 — Jun 2022 [monthly]

    Recruiting PHASE2

  4. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  5. Aug 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  6. Jun 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  7. May 2019 — Jun 2020 [monthly]

    Recruiting PHASE2

  8. Jan 2019 — May 2019 [monthly]

    Recruiting PHASE2

  9. Jun 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  10. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

    First recorded

Jan 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Cedars-Sinai Medical Center
Data source: Cedars-Sinai Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations