deltatrials
Recruiting NA INTERVENTIONAL 3-arm NCT03033251

High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease (HiFOLD)

High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease and Hypercapnic Respiratory Failure

Sponsor: Unity Health Toronto

Updated 12 times since 2017 Last updated: May 15, 2025 Started: Sep 2, 2018 Primary completion: Apr 11, 2025 Completion: Jul 1, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03033251, this NA trial focuses on Acute Hypercapnic Respiratory Failure and Acute Respiratory Distress and remains actively recruiting participants. Sponsored by Unity Health Toronto, it has been updated 12 times since 2018, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Feb 2017 – ~Sep 2017 · 7 months · monthly snapshotNot Yet Recruiting~Sep 2017 – ~Jun 2018 · 9 months · monthly snapshotRecruiting~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshotRecruiting~Mar 2019 – ~May 2019 · 2 months · monthly snapshotRecruiting~May 2019 – ~Jan 2021 · 20 months · monthly snapshotRecruiting~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshotRecruiting~Sep 2021 – ~Jul 2023 · 22 months · monthly snapshotRecruiting~Jul 2023 – ~Mar 2024 · 8 months · monthly snapshotUnknown Status~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshotRecruiting~Jun 2025 – present · 13 months · monthly snapshotRecruiting

Change History

12 versions recorded
  1. Jun 2025 — Present [monthly]

    Recruiting NA

  2. Sep 2024 — Jun 2025 [monthly]

    Recruiting NA

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting NA

  4. Mar 2024 — Jul 2024 [monthly]

    Recruiting NA

    Status: Unknown StatusRecruiting

  5. Jul 2023 — Mar 2024 [monthly]

    Unknown Status NA

    Status: RecruitingUnknown Status

Show 7 earlier versions
  1. Sep 2021 — Jul 2023 [monthly]

    Recruiting NA

  2. Jan 2021 — Sep 2021 [monthly]

    Recruiting NA

  3. May 2019 — Jan 2021 [monthly]

    Recruiting NA

  4. Mar 2019 — May 2019 [monthly]

    Recruiting NA

  5. Jun 2018 — Mar 2019 [monthly]

    Recruiting NA

  6. Sep 2017 — Jun 2018 [monthly]

    Recruiting NA

    Status: Not Yet RecruitingRecruiting

  7. Feb 2017 — Sep 2017 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Unity Health Toronto
Data source: Unity Health Toronto

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations