deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT03033576

Testing Treatment With Ipilimumab and Nivolumab Compared to Treatment With Ipilimumab Alone in Advanced Melanoma

A Phase II Randomized Study of Nivolumab (NSC-748726) With Ipilimumab (NSC-732442) or Ipilimumab Alone in Advanced Melanoma Patients Refractory to an Anti-PD1 or Anti-PD-L1 Agent

Sponsor: National Cancer Institute (NCI)

Conditions Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Melanoma of Unknown Primary Mucosal Melanoma Unresectable Cutaneous Melanoma Unresectable Melanoma
Interventions Ipilimumab Nivolumab
Updated 66 times since 2017 Last updated: Dec 21, 2024 Started: Oct 23, 2017 Primary completion: Sep 19, 2023 Completion: Mar 20, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Clinical Stage III Cutaneous Melanoma AJCC v8 and Clinical Stage IV Cutaneous Melanoma AJCC v8 and is currently completed. National Cancer Institute (NCI) leads this study, which shows 66 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Aug 2017 · 3 months · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~May 2018 · 30 days · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Jun 2023 · 9 months · monthly snapshot~Jun 2023 – ~Mar 2024 · 9 months · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jun 2024 · 2 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Dec 2024 · 2 months · monthly snapshot~Dec 2024 – ~Feb 2025 · 2 months · monthly snapshot~Feb 2025 – ~Sep 2025 · 7 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

66 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Feb 2025 — Sep 2025 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  3. Dec 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Oct 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 61 earlier versions

  1. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Apr 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Jun 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  7. Sep 2022 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

  8. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  9. May 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  10. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE2

  11. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

  12. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE2

  13. Nov 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE2

  14. Sep 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE2

  15. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  16. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE2

  17. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE2

  18. Feb 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE2

  19. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2

  20. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  21. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2

  22. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

  23. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  24. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  25. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  26. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  27. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2

  28. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  29. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  30. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  31. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  32. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  33. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  34. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  35. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  36. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  37. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  38. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  39. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  40. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  41. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  42. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  43. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  44. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  45. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  46. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  47. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  48. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  49. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  50. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  51. Apr 2018 — May 2018 [monthly]

    Recruiting PHASE2

  52. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE2

  53. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

  54. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE2

  55. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE2

  56. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  57. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE2

  58. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  59. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  60. May 2017 — Aug 2017 [monthly]

    Not Yet Recruiting PHASE2

  61. Feb 2017 — May 2017 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aberdeen, United States , Abington, United States , Adrian, United States , Aitkin, United States , Albuquerque, United States , American Fork, United States , Anaconda, United States , Anaheim, United States , Anchorage, United States , Antioch, United States and 370 more locations