Active Not Recruiting NA INTERVENTIONAL 2-arm NCT03033992

Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG

Feasibility Trial of Optune for Children With Recurrent or Progressive Supratentorial High-Grade Glioma or Ependymoma, and Feasibility and Efficacy Trial of Optune in Conjunction With Radiation Therapy for Children With Newly Diagnosed DIPG

Sponsor: American Lebanese Syrian Associated Charities

Conditions Diffuse Intrinsic Pontine Glioma Ependymoma Malignant Glioma

Interventions Concurrent Optune and RT followed by Optune System alone Optune System (NovoTTF-200A System, Tumor Treating Fields, TTFields)

Updated 25 times since 2017 Last updated: Mar 3, 2026 Started: Apr 4, 2017 Primary completion: May 22, 2031 Completion: Jul 21, 2031

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03033992, this NA trial focuses on Diffuse Intrinsic Pontine Glioma and Ependymoma and remains ongoing. Sponsored by American Lebanese Syrian Associated Charities, it has been updated 25 times since 2017, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

25 versions recorded

Mar 2026 — Present [monthly]

Active Not Recruiting NA
Sep 2025 — Mar 2026 [monthly]

Active Not Recruiting NA

Status: Recruiting → Active Not Recruiting
May 2025 — Sep 2025 [monthly]

Recruiting NA

Status: Active Not Recruiting → Recruiting
Mar 2025 — May 2025 [monthly]

Active Not Recruiting NA

Status: Recruiting → Active Not Recruiting
Oct 2024 — Mar 2025 [monthly]

Recruiting NA

▶ Show 20 earlier versions

Sep 2024 — Oct 2024 [monthly]

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Jul 2024 — Sep 2024 [monthly]

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Jun 2024 — Jul 2024 [monthly]

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May 2024 — Jun 2024 [monthly]

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Mar 2024 — May 2024 [monthly]

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Feb 2024 — Mar 2024 [monthly]

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Status: Active Not Recruiting → Recruiting
Jul 2023 — Feb 2024 [monthly]

Active Not Recruiting NA
Feb 2023 — Jul 2023 [monthly]

Active Not Recruiting NA
Sep 2022 — Feb 2023 [monthly]

Active Not Recruiting NA

Status: Recruiting → Active Not Recruiting
Oct 2021 — Sep 2022 [monthly]

Recruiting NA
Mar 2021 — Oct 2021 [monthly]

Recruiting NA
Jan 2021 — Mar 2021 [monthly]

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Dec 2020 — Jan 2021 [monthly]

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Oct 2019 — Dec 2020 [monthly]

Recruiting NA
Sep 2019 — Oct 2019 [monthly]

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Sep 2018 — Sep 2019 [monthly]

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Jun 2018 — Sep 2018 [monthly]

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Aug 2017 — Jun 2018 [monthly]

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Jun 2017 — Aug 2017 [monthly]

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Feb 2017 — Jun 2017 [monthly]

Recruiting NA

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

American Lebanese Syrian Associated Charities
Children's Oncology Group
National Cancer Institute (NCI)
NovoCure Ltd.
Pediatric Brain Tumor Consortium

Data source: Children's Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Aurora, United States , Cincinnati, United States , Houston, United States , Los Angeles, United States , Memphis, United States , New York, United States , Palo Alto, United States , Phoenix, United States , Pittsburgh, United States and 1 more location