Early Administration of Romidepsin and 3BNC117 in Treatment-naïve HIV Patients Starting ART (eCLEAR)
Early Administration of Latency Reversing Therapy and Broadly Neutralizing Antibodies to Limit the Establishment of the HIV-1 Reservoir During Initiation of Antiretroviral Treatment - a Randomized Controlled Trial
Sponsor: Aalborg University Hospital
Listed as NCT03041012, this PHASE2 trial focuses on Hiv and remains completed. Sponsored by Aalborg University Hospital, it has been updated 17 times since 2017, reflecting substantial change activity. This study is part of the global effort to build evidence for infectious disease interventions.
Study Description(click to expand)The study will be conducted among ART naïve HIV-1-infected patients.
Subjects will continue ART while receiving LRA romidepsin and/or bNAb 3BNC117.
The study will be conducted among ART naïve HIV-1-infected patients.
Subjects will continue ART while receiving LRA romidepsin and/or bNAb 3BNC117.
Status Flow
Change History
17 versions recorded-
Jan 2026 — Present [monthly]
Completed PHASE2
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Sep 2025 — Present [monthly]
Completed PHASE2
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May 2025 — Sep 2025 [monthly]
Completed PHASE2
Status: Unknown → Completed
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Sep 2024 — May 2025 [monthly]
Unknown PHASE2
-
Jul 2024 — Sep 2024 [monthly]
Unknown PHASE2
Status: Unknown Status → Unknown
▶ Show 12 earlier versions
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May 2023 — Jul 2024 [monthly]
Unknown Status PHASE2
Status: Active Not Recruiting → Unknown Status
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Oct 2021 — May 2023 [monthly]
Active Not Recruiting PHASE2
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May 2021 — Oct 2021 [monthly]
Active Not Recruiting PHASE2
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Jan 2021 — May 2021 [monthly]
Active Not Recruiting PHASE2
-
Oct 2020 — Jan 2021 [monthly]
Active Not Recruiting PHASE2
Status: Recruiting → Active Not Recruiting
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Nov 2019 — Oct 2020 [monthly]
Recruiting PHASE2
-
Jun 2019 — Nov 2019 [monthly]
Recruiting PHASE2
-
May 2019 — Jun 2019 [monthly]
Recruiting PHASE2
-
Jan 2019 — May 2019 [monthly]
Recruiting PHASE2
-
Jun 2018 — Jan 2019 [monthly]
Recruiting PHASE2
-
May 2017 — Jun 2018 [monthly]
Recruiting PHASE2
-
Feb 2017 — May 2017 [monthly]
Recruiting PHASE2
First recorded
Jan 2017
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Aalborg University Hospital
- Aarhus University Hospital
- Hammersmith Hospitals NHS Trust
- Herning Hospital
- Hvidovre University Hospital
- Odense University Hospital
- Rigshospitalet, Denmark
- St Mary's Hospital, London
For direct contact, visit the study record on ClinicalTrials.gov .