deltatrials
Terminated PHASE1/PHASE2 INTERVENTIONAL 3-arm NCT03041324

Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-913 in Subjects With MPS II

A Phase I / 2, Multicenter, Open-label, Single-dose, Dose-ranging Study to Assess the Safety and Tolerability of SB-913, a rAAV2/6-based Gene Transfer in Subjects With Mucopolysaccharidosis II (MPS II)

Sponsor: Sangamo Therapeutics

Conditions MPS II Mucopolysaccharidosis II
Interventions SB-913
Updated 25 times since 2017 Last updated: Oct 21, 2022 Started: May 11, 2017 Primary completion: May 7, 2021 Completion: May 7, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

All nine subjects dosed in the study have rolled over to the Long-Term Follow-up Study IVPRP-LT01 \[NCT04628871\]

Other terminated trials from Sangamo Therapeutics

See all terminations from Sangamo Therapeutics

Listed as NCT03041324, this PHASE1/PHASE2 trial focuses on MPS II and Mucopolysaccharidosis II and remains terminated or withdrawn. Sponsored by Sangamo Therapeutics, it has been updated 25 times since 2017, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Sep 2017 · 3 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Mar 2018 · 3 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Oct 2018 · 3 months · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Aug 2019 · 6 months · monthly snapshot~Aug 2019 – ~Dec 2019 · 4 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Sep 2022 · 9 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Jul 2024 · 18 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 21 months · monthly snapshot

Change History

25 versions recorded

  1. Sep 2024 — Present [monthly]

    Terminated PHASE1/PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  3. Jan 2023 — Jul 2024 [monthly]

    Terminated PHASE1_PHASE2

  4. Dec 2022 — Jan 2023 [monthly]

    Terminated PHASE1_PHASE2

  5. Nov 2022 — Dec 2022 [monthly]

    Terminated PHASE1_PHASE2

▶ Show 20 earlier versions

  1. Sep 2022 — Nov 2022 [monthly]

    Terminated PHASE1_PHASE2

  2. Dec 2021 — Sep 2022 [monthly]

    Terminated PHASE1_PHASE2

  3. Sep 2021 — Dec 2021 [monthly]

    Terminated PHASE1_PHASE2

    Status: Active Not Recruiting → Terminated

  4. Apr 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  6. Jan 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  7. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  8. Aug 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting · Phase: PHASE1 → PHASE1_PHASE2

  9. Feb 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  10. Dec 2018 — Feb 2019 [monthly]

    Recruiting PHASE1

  11. Oct 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  12. Jul 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  13. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

  14. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  15. Dec 2017 — Mar 2018 [monthly]

    Recruiting PHASE1

  16. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE1

  17. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE1

  18. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE1

  19. Jun 2017 — Sep 2017 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  20. Feb 2017 — Jun 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Sangamo Therapeutics
Data source: Sangamo Therapeutics

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations