deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT03053440

A Study Comparing BGB-3111 and Ibrutinib in Participants With Waldenström's Macroglobulinemia (WM) (ASPEN)

A Phase 3, Randomized, Open-Label, Multicenter Study Comparing the Efficacy and Safety of the Bruton's Tyrosine Kinase (BTK) Inhibitors BGB-3111 and Ibrutinib in Subjects With Waldenström's Macroglobulinemia (WM)

Sponsor: BeiGene

Conditions Waldenström's Macroglobulinemia
Interventions BGB-3111 Ibrutinib
Updated 22 times since 2017 Last updated: Oct 23, 2024 Started: Jan 25, 2017 Primary completion: Jun 21, 2022 Completion: Jun 21, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Waldenström's Macroglobulinemia, this trial is completed. The trial is conducted by BeiGene and has accumulated 22 data snapshots since 2017. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Feb 2017 – ~Jul 2017 · 5 months · monthly snapshot~Jul 2017 – ~Nov 2017 · 4 months · monthly snapshot~Nov 2017 – ~Jun 2018 · 7 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Jan 2019 · 5 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Aug 2019 · 6 months · monthly snapshot~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Jan 2021 · 8 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Mar 2022 · 6 months · monthly snapshot~Mar 2022 – ~Sep 2022 · 6 months · monthly snapshot~Sep 2022 – ~Jul 2023 · 10 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Sep 2025 · 10 months · monthly snapshot~Sep 2025 – present · 9 months · monthly snapshot

Change History

22 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Nov 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Nov 2024 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Jul 2023 — Jul 2024 [monthly]

    Completed PHASE3

▶ Show 17 earlier versions

  1. Sep 2022 — Jul 2023 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  2. Mar 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE3

  4. May 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  5. Jan 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE3

  6. May 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  7. Feb 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  8. Dec 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  9. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE3

  10. Aug 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  11. Feb 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE3

  12. Jan 2019 — Feb 2019 [monthly]

    Active Not Recruiting PHASE3

  13. Aug 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  14. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  15. Nov 2017 — Jun 2018 [monthly]

    Recruiting PHASE3

  16. Jul 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

  17. Feb 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

    First recorded

Jan 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • BeiGene
Data source: BeiGene

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Amsterdam, Netherlands , Athens, Greece , Badalona, Spain , Barcelona, Spain , Bedford PK, Australia , Bialystok, Poland , Bologna, Italy , Boston, United States , Bournemouth, United Kingdom , Brescia, Italy and 44 more locations