deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT03087591

APN401 in Treating Patients With Recurrent or Metastatic Pancreatic Cancer, Colorectal Cancer, or Other Solid Tumors That Cannot Be Removed by Surgery

Safety and Immunologic Activity of Multiple Infusions of APN401

Sponsor: National Cancer Institute (NCI)

Conditions Metastatic Malignant Neoplasm in the Brain Metastatic Solid Neoplasm Recurrent Colorectal Carcinoma Recurrent Pancreatic Carcinoma Recurrent Solid Neoplasm Stage IV Colorectal Cancer Stage IV Pancreatic Cancer Stage IVA Colorectal Cancer Stage IVA Pancreatic Cancer Stage IVB Colorectal Cancer Stage IVB Pancreatic Cancer Unresectable Solid Neoplasm
Interventions Laboratory Biomarker Analysis siRNA-transfected Peripheral Blood Mononuclear Cells (PBMC) APN401
Updated 17 times since 2017 Last updated: Sep 17, 2024 Started: Apr 28, 2017 Primary completion: Jul 31, 2019 Completion: Dec 8, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Metastatic Malignant Neoplasm in the Brain and Metastatic Solid Neoplasm and is currently completed. National Cancer Institute (NCI) leads this study, which shows 17 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Jun 2018 · 12 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Nov 2018 · 3 months · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~May 2019 · 4 months · monthly snapshot~May 2019 – ~Aug 2019 · 3 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Feb 2020 · 4 months · monthly snapshot~Feb 2020 – ~Jan 2021 · 11 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Sep 2022 · 9 months · monthly snapshot~Sep 2022 – ~Jul 2024 · 22 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – present · 20 months · monthly snapshot

Change History

17 versions recorded

  1. Nov 2024 — Present [monthly]

    Completed PHASE1

  2. Sep 2024 — Nov 2024 [monthly]

    Completed PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  4. Sep 2022 — Jul 2024 [monthly]

    Completed PHASE1

  5. Dec 2021 — Sep 2022 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

▶ Show 12 earlier versions

  1. Jan 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  3. Oct 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE1

    Status: Suspended → Active Not Recruiting

  4. Sep 2019 — Oct 2019 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  5. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  6. May 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  7. Jan 2019 — May 2019 [monthly]

    Recruiting PHASE1

  8. Nov 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

  9. Aug 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  10. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  11. Jun 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  12. May 2017 — Jun 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Apr 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
  • Wake Forest University Health Sciences
Data source: Wake Forest University Health Sciences

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations