Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT03089905

A Study to Compare the Long-term Outcomes After Two Different Anaesthetics (TREX)

Neurodevelopmental Outcome After Standard Dose Sevoflurane Versus Low-dose Sevoflurane/Dexmedetomidine/Remifentanil Anaesthesia in Young Children- The TREX Trial

Sponsor: Baylor College of Medicine

Conditions Anesthesia Child Development Neurotoxicity

Interventions Dexmedetomidine Remifentanil Sevoflurane

Updated 19 times since 2017 Last updated: Jul 30, 2025 Started: Aug 10, 2017 Primary completion: Mar 31, 2026 Completion: Jun 30, 2026

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Anesthesia and Child Development, this trial is ongoing. The trial is conducted by Baylor College of Medicine and has accumulated 19 data snapshots since 2017. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

19 versions recorded

Sep 2025 — Present [monthly]

Active Not Recruiting PHASE3
Sep 2024 — Sep 2025 [monthly]

Active Not Recruiting PHASE3
Aug 2024 — Sep 2024 [monthly]

Active Not Recruiting PHASE3
Jul 2024 — Aug 2024 [monthly]

Active Not Recruiting PHASE3
Nov 2023 — Jul 2024 [monthly]

Active Not Recruiting PHASE3

▶ Show 14 earlier versions

Jun 2023 — Nov 2023 [monthly]

Active Not Recruiting PHASE3

Status: Recruiting → Active Not Recruiting
Mar 2023 — Jun 2023 [monthly]

Recruiting PHASE3
Sep 2022 — Mar 2023 [monthly]

Recruiting PHASE3
Apr 2022 — Sep 2022 [monthly]

Recruiting PHASE3
Oct 2021 — Apr 2022 [monthly]

Recruiting PHASE3
May 2021 — Oct 2021 [monthly]

Recruiting PHASE3
Jan 2021 — May 2021 [monthly]

Recruiting PHASE3
Nov 2020 — Jan 2021 [monthly]

Recruiting PHASE3
Sep 2020 — Nov 2020 [monthly]

Recruiting PHASE3
Mar 2019 — Sep 2020 [monthly]

Recruiting PHASE3
Jun 2018 — Mar 2019 [monthly]

Recruiting PHASE3
Oct 2017 — Jun 2018 [monthly]

Recruiting PHASE3
Sep 2017 — Oct 2017 [monthly]

Recruiting PHASE3

Status: Not Yet Recruiting → Recruiting
May 2017 — Sep 2017 [monthly]

Not Yet Recruiting PHASE3

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Baylor College of Medicine
Boston Children's Hospital
Children's Hospital of Philadelphia
Flinders Medical Centre
Istituto Giannina Gaslini
Murdoch Childrens Research Institute
Perth Children's Hospital
Queensland Children's Hospital
Royal Children's Hospital
Sydney Children's Hospitals Network
The Cleveland Clinic
University of Texas, Southwestern Medical Center at Dallas
Women and Children's Hospital

Data source: Murdoch Childrens Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Adelaide, Australia , Alessandria, Italy , Bedford Park, Australia , Bologna, Italy , Boston, United States , Brisbane, Australia , Cleveland, United States , Dallas, United States , Florence, Italy , Genova, Italy and 10 more locations