deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT03106740

Evaluating the Role of Neuroinflammation in Low Back Pain (IGNITE)

Imaging Glia-mediated NeuroInflammation and Treatment Efficacy (the IGNITE Study)

Sponsor: Marco Loggia

Conditions Back Ache Back Pain Lower Back Chronic Back Pain With Radiation Back Pain Without Radiation Low Back Pain Pain, Chronic
Interventions Magnetic Resonance-Positron Emission Tomography Imaging Minocycline Hydrochloride 100mg Capsule Placebo Capsule
Updated 15 times since 2017 Last updated: Feb 9, 2026 Started: Oct 10, 2017 Primary completion: Apr 30, 2024 Completion: Apr 30, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Back Ache and Back Pain Lower Back Chronic and is currently completed. Marco Loggia leads this study, which shows 15 recorded versions since 2017 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~May 2017 – ~Sep 2017 · 4 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Apr 2018 · 6 months · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Oct 2019 · 16 months · monthly snapshot~Oct 2019 – ~Mar 2020 · 5 months · monthly snapshot~Mar 2020 – ~Jan 2021 · 10 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Oct 2023 · 24 months · monthly snapshot~Oct 2023 – ~Mar 2024 · 5 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshot~Jun 2025 – ~Feb 2026 · 8 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

15 versions recorded

  1. Feb 2026 — Present [monthly]

    Completed PHASE2

  2. Jun 2025 — Feb 2026 [monthly]

    Completed PHASE2

  3. Sep 2024 — Jun 2025 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  5. Mar 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Unknown Status → Active Not Recruiting

▶ Show 10 earlier versions

  1. Oct 2023 — Mar 2024 [monthly]

    Unknown Status PHASE2

    Status: Recruiting → Unknown Status

  2. Oct 2021 — Oct 2023 [monthly]

    Recruiting PHASE2

  3. Jan 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  4. Mar 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  5. Oct 2019 — Mar 2020 [monthly]

    Recruiting PHASE2

  6. Jun 2018 — Oct 2019 [monthly]

    Recruiting PHASE2

  7. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  8. Oct 2017 — Apr 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  9. Sep 2017 — Oct 2017 [monthly]

    Not Yet Recruiting PHASE2

  10. May 2017 — Sep 2017 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Marco Loggia
  • National Institute of Neurological Disorders and Stroke (NINDS)
Data source: Massachusetts General Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations