deltatrials
Completed PHASE2 INTERVENTIONAL 5-arm NCT03110770

VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents (DNA)

VRC 705: A Phase 2/2B, Randomized Trial to Evaluate the Safety, Immunogenicity and Efficacy of a Zika Virus DNA Vaccine in Healthy Adults and Adolescents

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Conditions Flaviviral Diseases Flaviviridae Infections Flavivirus Infections RNA Virus Infections Virus Diseases Zika Virus Zika Virus Infection
Interventions VRC-PBSPLA043-00-VP VRC-ZKADNA090-00-VP
Updated 24 times since 2017 Last updated: Jan 8, 2024 Started: Mar 29, 2017 Primary completion: Oct 4, 2019 Completion: Oct 4, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Flaviviral Diseases and Flaviviridae Infections, this trial is completed. The trial is conducted by National Institute of Allergy and Infectious Diseases (NIAID) and has accumulated 24 data snapshots since 2017. Infectious disease trials contribute critical data for public health response and treatment development.

Status Flow

~May 2017 – ~Jul 2017 · 2 months · monthly snapshot~Jul 2017 – ~Sep 2017 · 2 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Apr 2018 · 3 months · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Feb 2019 · 3 months · monthly snapshot~Feb 2019 – ~Jun 2019 · 4 months · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Jan 2020 · 5 months · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Mar 2023 · 21 months · monthly snapshot~Mar 2023 – ~Feb 2024 · 11 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

24 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Feb 2024 — Jul 2024 [monthly]

    Completed PHASE2

  5. Mar 2023 — Feb 2024 [monthly]

    Completed PHASE2

▶ Show 19 earlier versions

  1. Jun 2021 — Mar 2023 [monthly]

    Completed PHASE2

  2. Jan 2021 — Jun 2021 [monthly]

    Completed PHASE2

  3. Jan 2020 — Jan 2021 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  4. Aug 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE2

  5. Jun 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE2

  6. Feb 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  7. Nov 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  8. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  9. Aug 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  10. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  11. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  12. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  13. Jan 2018 — Apr 2018 [monthly]

    Recruiting PHASE2

  14. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE2

  15. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  16. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE2

  17. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  18. Jul 2017 — Sep 2017 [monthly]

    Recruiting PHASE2

    Status: Enrolling By Invitation → Recruiting

  19. May 2017 — Jul 2017 [monthly]

    Enrolling By Invitation PHASE2

    First recorded

Mar 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute of Allergy and Infectious Diseases (NIAID)
Data source: National Institute of Allergy and Infectious Diseases (NIAID)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Barranquilla, Colombia , Belo Horizonte, Brazil , Bucaramanga, Colombia , Edinburg, United States , Guadalajara, Mexico , Guayaquil, Ecuador , Houston, United States , Iquitos, Peru , Lima, Peru , Miami, United States and 5 more locations