deltatrials
Completed PHASE3 INTERVENTIONAL 4-arm NCT03112174

Study of Ibrutinib Combined With Venetoclax in Subjects With Mantle Cell Lymphoma (MCL) (SYMPATICO)

Phase 3 Study of Ibrutinib in Combination With Venetoclax in Subjects With Mantle Cell Lymphoma

Sponsor: Janssen Research & Development, LLC

Conditions Mantle-Cell Lymphoma
Interventions Ibrutinib Placebo Oral tablet to match Venetoclax Venetoclax
Updated 46 times since 2017 Last updated: Jul 2, 2025 Started: Jun 19, 2017 Primary completion: Jun 26, 2024 Completion: Jun 27, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Mantle-Cell Lymphoma, this trial is completed. The trial is conducted by Janssen Research & Development, LLC and has accumulated 46 data snapshots since 2017. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~May 2017 – ~Sep 2017 · 4 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Jan 2018 · 3 months · monthly snapshot~Jan 2018 – ~Mar 2018 · 59 days · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Sep 2021 · 6 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Sep 2022 · 7 months · monthly snapshot~Sep 2022 – ~Mar 2023 · 6 months · monthly snapshot~Mar 2023 – ~Oct 2023 · 7 months · monthly snapshot~Oct 2023 – ~Jul 2024 · 9 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Aug 2025 · 11 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

46 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Aug 2025 — Sep 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Aug 2025 [monthly]

    Completed PHASE3

  4. Aug 2024 — Sep 2024 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  5. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE3

▶ Show 41 earlier versions

  1. Oct 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  2. Mar 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2022 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  4. Feb 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  5. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  6. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  7. Sep 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  8. Mar 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  9. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  10. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  11. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  12. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  13. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  14. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  15. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  16. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  17. May 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  18. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

    Status: Active Not Recruiting → Recruiting

  19. Feb 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  20. Dec 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  21. Oct 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  22. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  23. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  24. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  25. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  26. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  27. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  28. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  29. Jan 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  30. Nov 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  31. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  32. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  33. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  34. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  35. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  36. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  37. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE3

  38. Jan 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

  39. Oct 2017 — Jan 2018 [monthly]

    Recruiting PHASE3

  40. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  41. May 2017 — Sep 2017 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
  • Pharmacyclics LLC.
Data source: Pharmacyclics LLC.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albury, Australia , Alessandria, Italy , Alexandroupoli, Greece , Ankara, Turkey (Türkiye) , Antwerp, Belgium , Athens, Greece , Auchenflower, Australia , Badalona, Spain , Barcelona, Spain , Bergamo, Italy and 96 more locations