deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 2-arm NCT03120624

VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Stage IV or Recurrent Endometrial Cancer

Phase I Trial of Intravenous Administration of Vesicular Stomatitis Virus Genetically Engineered to Express Thyroidal Sodium Iodide Symporter (NIS) and Human Interferon Beta (hIFNb), in Patients With Metastatic or Recurrent Endometrial Cancer

Sponsor: Mayo Clinic

Conditions Metastatic Endometrial Carcinoma Recurrent Endometrial Adenocarcinoma Recurrent Endometrial Carcinoma Recurrent Endometrial Clear Cell Adenocarcinoma Recurrent Endometrial Endometrioid Adenocarcinoma Recurrent Endometrial Mixed Cell Adenocarcinoma Recurrent Endometrial Serous Adenocarcinoma Recurrent Endometrial Undifferentiated Carcinoma Recurrent Uterine Corpus Carcinosarcoma Stage IV Uterine Corpus Cancer AJCC v7
Interventions Biopsy Biospecimen Collection Computed Tomography Fluorine F 18 Tetrafluoroborate Pharmacological Study Positron Emission Tomography Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter Ruxolitinib Phosphate Technetium Tc-99m Sodium Pertechnetate
Updated 28 times since 2017 Last updated: Jan 15, 2026 Started: Sep 15, 2017 Primary completion: Aug 29, 2023 Completion: Jan 1, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Metastatic Endometrial Carcinoma and Recurrent Endometrial Adenocarcinoma and is currently ongoing. Mayo Clinic leads this study, which shows 28 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jun 2017 – ~Oct 2017 · 4 months · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Apr 2018 · 3 months · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Mar 2019 · 3 months · monthly snapshot~Mar 2019 – ~Jul 2019 · 4 months · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Jun 2020 · 9 months · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~Jun 2022 · 4 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Jun 2023 · 9 months · monthly snapshot~Jun 2023 – ~Sep 2023 · 3 months · monthly snapshot~Sep 2023 – ~Dec 2023 · 3 months · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Oct 2025 · 11 months · monthly snapshot~Oct 2025 – ~Feb 2026 · 4 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

28 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Oct 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Nov 2024 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 23 earlier versions

  1. Feb 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  2. Dec 2023 — Feb 2024 [monthly]

    Recruiting PHASE1

  3. Sep 2023 — Dec 2023 [monthly]

    Recruiting PHASE1

    Status: Active Not Recruiting → Recruiting

  4. Jun 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  5. Sep 2022 — Jun 2023 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  6. Jun 2022 — Sep 2022 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  7. Feb 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  8. Sep 2021 — Feb 2022 [monthly]

    Recruiting PHASE1

  9. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  10. Sep 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  11. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  12. Jun 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  13. Sep 2019 — Jun 2020 [monthly]

    Recruiting PHASE1

  14. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  15. Mar 2019 — Jul 2019 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  16. Dec 2018 — Mar 2019 [monthly]

    Recruiting PHASE1

  17. Oct 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  18. Jun 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  19. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

    Status: Active Not Recruiting → Recruiting

  20. Jan 2018 — Apr 2018 [monthly]

    Active Not Recruiting PHASE1

    Status: Suspended → Active Not Recruiting

  21. Dec 2017 — Jan 2018 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  22. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  23. Jun 2017 — Oct 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Mayo Clinic
  • National Cancer Institute (NCI)
Data source: Mayo Clinic

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations