deltatrials
Terminated PHASE1/PHASE2 INTERVENTIONAL 6-arm NCT03138889

Bempegaldesleukin and Pembrolizumab With or Without Chemotherapy in Locally Advanced or Metastatic Solid Tumors (PROPEL)

A Phase 1/2, Open-Label, Multicenter Study to Investigate the Safety and Preliminary Efficacy of Combined Bempegaldesleukin (NKTR-214) and Pembrolizumab With or Without Chemotherapy in Patients With Locally Advanced or Metastatic Solid Tumors

Sponsor: Nektar Therapeutics

Conditions Non-Small Cell Lung Cancer
Interventions Atezolizumab Carboplatin Cisplatin NKTR-214 Nab paclitaxel Paclitaxel Pembrolizumab Pemetrexed
Updated 40 times since 2017 Last updated: Mar 8, 2023 Started: Jun 9, 2017 Primary completion: Jul 5, 2022 Completion: Aug 24, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Sponsor decision

Other terminated trials from Nektar Therapeutics

See all terminations from Nektar Therapeutics

A PHASE1/PHASE2 clinical study on Non-Small Cell Lung Cancer, this trial is terminated or withdrawn. The trial is conducted by Nektar Therapeutics and has accumulated 40 data snapshots since 2017. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Sep 2017 · 2 months · monthly snapshot~Sep 2017 – ~Dec 2017 · 3 months · monthly snapshot~Dec 2017 – ~Mar 2018 · 3 months · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Dec 2019 · 11 months · monthly snapshot~Dec 2019 – ~Mar 2020 · 3 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Mar 2022 · 59 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Apr 2023 · 7 months · monthly snapshot~Apr 2023 – ~Jul 2024 · 15 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

40 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE1/PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  4. Apr 2023 — Jul 2024 [monthly]

    Terminated PHASE1_PHASE2

  5. Sep 2022 — Apr 2023 [monthly]

    Terminated PHASE1_PHASE2

    Status: Active Not Recruiting → Terminated

▶ Show 35 earlier versions

  1. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  2. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1_PHASE2

  3. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1_PHASE2

  4. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1_PHASE2

  5. Jan 2022 — Mar 2022 [monthly]

    Recruiting PHASE1_PHASE2

  6. Nov 2021 — Jan 2022 [monthly]

    Recruiting PHASE1_PHASE2

  7. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1_PHASE2

  8. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1_PHASE2

  9. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1_PHASE2

  10. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1_PHASE2

  11. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1_PHASE2

  12. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1_PHASE2

  13. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1_PHASE2

  14. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1_PHASE2

  15. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  16. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1_PHASE2

  17. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1_PHASE2

  18. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1_PHASE2

  19. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1_PHASE2

  20. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1_PHASE2

  21. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1_PHASE2

  22. Mar 2020 — May 2020 [monthly]

    Recruiting PHASE1_PHASE2

  23. Dec 2019 — Mar 2020 [monthly]

    Recruiting PHASE1_PHASE2

    Phase: PHASE1 → PHASE1_PHASE2

  24. Jan 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  25. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

  26. Oct 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  27. Aug 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  28. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  29. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

  30. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  31. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE1

  32. Dec 2017 — Mar 2018 [monthly]

    Recruiting PHASE1

  33. Sep 2017 — Dec 2017 [monthly]

    Recruiting PHASE1

  34. Jul 2017 — Sep 2017 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  35. Jun 2017 — Jul 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Nektar Therapeutics
Data source: Nektar Therapeutics

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Augusta, United States , Aurora, United States , Barcelona, Spain , Berlin, Germany , Billings, United States , Detroit, United States , Durham, United States , Fairfax, United States , Fayetteville, United States , Gauting, Germany and 24 more locations