deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 2-arm NCT03150329

Pembrolizumab and Vorinostat in Patients With Relapsed or Refractory DLBCL, FCL or HL.

A Phase 1 Study of Pembrolizumab Plus Vorinostat for Relapsed or Refractory Diffuse Large B-Cell Lymphoma, Follicular Lymphoma, and Hodgkin Lymphoma

Sponsor: City of Hope Medical Center

Conditions Grade 3b Follicular Lymphoma Recurrent B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between DLBCL and Classic HL Recurrent Classic Hodgkin Lymphoma Recurrent Diffuse Large B-Cell Lymphoma Recurrent Follicular Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3a Follicular Lymphoma Recurrent Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma Recurrent Transformed Non-Hodgkin Lymphoma Refractory B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between DLBCL and Classic HL Refractory Classic Hodgkin Lymphoma Refractory Diffuse Large B-Cell Lymphoma Refractory Follicular Lymphoma Refractory Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma Refractory Transformed Non-Hodgkin Lymphoma
Interventions Laboratory Biomarker Analysis Pembrolizumab Vorinostat
Updated 21 times since 2017 Last updated: Aug 18, 2025 Started: Jul 18, 2017 Primary completion: Jun 23, 2023 Completion: Jul 1, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03150329, this PHASE1 trial focuses on Grade 3b Follicular Lymphoma and Recurrent B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between DLBCL and Classic HL and remains ongoing. Sponsored by City of Hope Medical Center, it has been updated 21 times since 2017, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Feb 2019 · 6 months · monthly snapshot~Feb 2019 – ~Jul 2019 · 5 months · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Dec 2019 · 3 months · monthly snapshot~Dec 2019 – ~Jan 2021 · 13 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2022 · 13 months · monthly snapshot~Mar 2022 – ~Jul 2022 · 4 months · monthly snapshot~Jul 2022 – ~Feb 2023 · 7 months · monthly snapshot~Feb 2023 – ~Oct 2023 · 8 months · monthly snapshot~Oct 2023 – ~Mar 2024 · 5 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Oct 2025 · 8 months · monthly snapshot~Oct 2025 – present · 11 months · monthly snapshot

Change History

21 versions recorded

  1. Oct 2025 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Mar 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 16 earlier versions

  1. Oct 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1

  3. Jul 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1

  4. Mar 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  5. Feb 2021 — Mar 2022 [monthly]

    Recruiting PHASE1

  6. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  7. Dec 2019 — Jan 2021 [monthly]

    Recruiting PHASE1

  8. Sep 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  9. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  10. Feb 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  11. Aug 2018 — Feb 2019 [monthly]

    Recruiting PHASE1

  12. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  13. Oct 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  14. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE1

  15. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  16. Jun 2017 — Aug 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • City of Hope Medical Center
  • National Cancer Institute (NCI)
Data source: City of Hope Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations