deltatrials
Completed PHASE3 INTERVENTIONAL 3-arm NCT03155347

An Efficacy and Safety Study of Subcutaneous Tocilizumab in Combination With Methotrexate (MTX) and as Monotherapy Versus MTX in Participants With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Current Disease-Modifying Antirheumatic Drug (DMARD) Therapy

A Randomized, Multi-Center, Double Blind, Parallel-Group Study to Evaluate the Efficacy and Safety of Subcutaneous (SC) Tocilizumab (TCZ) in Combination With Methotrexate (MTX) and as Monotherapy Versus MTX in Patients With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Current DMARD Therapy

Sponsor: Hoffmann-La Roche

Conditions Rheumatoid Arthritis
Interventions MTX Placebo Matched to MTX Placebo Matched to Tocilizumab Tocilizumab
Updated 44 times since 2017 Last updated: Nov 27, 2023 Started: Aug 2, 2017 Primary completion: Aug 8, 2022 Completion: Aug 8, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Rheumatoid Arthritis, this trial is completed. The trial is conducted by Hoffmann-La Roche and has accumulated 44 data snapshots since 2017. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Oct 2017 · 3 months · monthly snapshot~Oct 2017 – ~Feb 2018 · 4 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Nov 2018 · 5 months · monthly snapshot~Nov 2018 – ~Apr 2019 · 5 months · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Nov 2019 · 4 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Jun 2022 · 3 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Dec 2023 · 11 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

44 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Dec 2023 — Jul 2024 [monthly]

    Completed PHASE3

  5. Jan 2023 — Dec 2023 [monthly]

    Completed PHASE3

▶ Show 39 earlier versions

  1. Sep 2022 — Jan 2023 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  2. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  3. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  4. Mar 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  5. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  6. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

    Status: Active Not Recruiting → Recruiting

  7. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  8. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  9. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  10. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  11. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  12. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  13. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE3

  14. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  15. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  16. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  17. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  18. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  19. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  20. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  21. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  22. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  23. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  24. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  25. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

  26. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE3

  27. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  28. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  29. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  30. Jul 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  31. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  32. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  33. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  34. Nov 2018 — Apr 2019 [monthly]

    Recruiting PHASE3

  35. Jun 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  36. Feb 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  37. Oct 2017 — Feb 2018 [monthly]

    Recruiting PHASE3

  38. Jul 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  39. Jun 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Baotou, China , Beijing, China , Bengbu, China , Changchun, China , Chengdu, China , Guangzhou, China , Harbin, China , Hefei, China , Hohhot, China , Jiaxing, China and 7 more locations