deltatrials
Active Not Recruiting PHASE4 INTERVENTIONAL 5-arm NCT03180034

Comparing One or Two Doses of the Human Papillomavirus Vaccine for the Prevention of Human Papillomavirus Infection, ESCUDDO Study (ESCUDDO)

A Scientific Evaluation of One or Two Doses of Vaccine Against Human Papillomavirus: the ESCUDDO Study (Estudio de Comparacion de Una y Dos Dosis de Vacunas Contra el Virus de Papiloma Humano (VPH))

Sponsor: Bill and Melinda Gates Foundation

Conditions Human Papillomavirus Infection Human Papillomavirus-Related Cervical Carcinoma
Interventions Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed Questionnaire Administration Recombinant Human Papillomavirus Bivalent Vaccine Recombinant Human Papillomavirus Nonavalent Vaccine
Updated 38 times since 2017 Last updated: Sep 3, 2025 Started: Nov 29, 2017 Primary completion: Aug 21, 2025 Completion: Aug 1, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE4 clinical study on Human Papillomavirus Infection and Human Papillomavirus-Related Cervical Carcinoma, this trial is ongoing. The trial is conducted by Bill and Melinda Gates Foundation and has accumulated 38 data snapshots since 2017. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jun 2017 – ~Oct 2017 · 4 months · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Jan 2018 · 2 months · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Nov 2019 · 6 months · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~May 2020 · 4 months · monthly snapshot~May 2020 – ~Nov 2020 · 6 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Jan 2022 · 12 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2023 · 14 months · monthly snapshot~Nov 2023 – ~May 2024 · 6 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Oct 2025 · 4 months · monthly snapshot~Oct 2025 – present · 8 months · monthly snapshot

Change History

38 versions recorded

  1. Oct 2025 — Present [monthly]

    Active Not Recruiting PHASE4

  2. Jun 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE4

  3. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE4

  4. Mar 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE4

  5. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE4

▶ Show 33 earlier versions

  1. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE4

  2. Dec 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE4

    Status: Enrolling By Invitation → Active Not Recruiting

  3. Nov 2024 — Dec 2024 [monthly]

    Enrolling By Invitation PHASE4

  4. Sep 2024 — Nov 2024 [monthly]

    Enrolling By Invitation PHASE4

  5. Jul 2024 — Sep 2024 [monthly]

    Enrolling By Invitation PHASE4

  6. May 2024 — Jul 2024 [monthly]

    Enrolling By Invitation PHASE4

  7. Nov 2023 — May 2024 [monthly]

    Enrolling By Invitation PHASE4

  8. Sep 2022 — Nov 2023 [monthly]

    Enrolling By Invitation PHASE4

    Status: Active Not Recruiting → Enrolling By Invitation

  9. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE4

  10. May 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE4

  11. Feb 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE4

  12. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE4

  13. Jan 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE4

    Status: Completed → Active Not Recruiting

  14. Nov 2020 — Jan 2021 [monthly]

    Completed PHASE4

    Status: Active Not Recruiting → Completed

  15. May 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

  16. Jan 2020 — May 2020 [monthly]

    Recruiting PHASE4

  17. Nov 2019 — Jan 2020 [monthly]

    Recruiting PHASE4

  18. May 2019 — Nov 2019 [monthly]

    Recruiting PHASE4

  19. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE4

  20. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE4

  21. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE4

  22. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE4

  23. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE4

  24. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE4

  25. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE4

  26. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE4

  27. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE4

  28. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE4

  29. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE4

  30. Jan 2018 — Jun 2018 [monthly]

    Recruiting PHASE4

    Status: Not Yet Recruiting → Recruiting

  31. Nov 2017 — Jan 2018 [monthly]

    Not Yet Recruiting PHASE4

  32. Oct 2017 — Nov 2017 [monthly]

    Not Yet Recruiting PHASE4

  33. Jun 2017 — Oct 2017 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bill and Melinda Gates Foundation
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations