deltatrials
Recruiting PHASE1 INTERVENTIONAL 1-arm NCT03198546

GPC3-CAR-T Cells for Immunotherapy of Cancer With GPC3 Expression

CAR-T Cell Targeting GPC3 for Immunotherapy of Hepatocellular Carcinoma: Phase I Clinical Trial

Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Conditions CAR GPC3 Gene Inactivation Hepatocellular Carcinoma Immunotherapy Squamous Cell Lung Cancer T Cell
Interventions GPC3 and/or TGFβ targeting CAR-T cells
Updated 9 times since 2017 Last updated: Jun 22, 2024 Started: Jul 1, 2017 Primary completion: Aug 1, 2029 Completion: Aug 1, 2036
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates CAR and GPC3 Gene Inactivation and is currently actively recruiting participants. First Affiliated Hospital, Sun Yat-Sen University leads this study, which shows 9 recorded versions since 2017 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Aug 2017 – ~Jun 2018 · 10 months · monthly snapshotRecruiting~Jun 2018 – ~Nov 2018 · 5 months · monthly snapshotRecruiting~Nov 2018 – ~Oct 2019 · 11 months · monthly snapshotRecruiting~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshotRecruiting~Dec 2019 – ~Jan 2021 · 13 months · monthly snapshotRecruiting~Jan 2021 – ~Mar 2023 · 26 months · monthly snapshotRecruiting~Mar 2023 – ~Jul 2024 · 16 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – present · 22 months · monthly snapshotRecruiting

Change History

9 versions recorded

  1. Sep 2024 — Present [monthly]

    Recruiting PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  3. Mar 2023 — Jul 2024 [monthly]

    Recruiting PHASE1

  4. Jan 2021 — Mar 2023 [monthly]

    Recruiting PHASE1

  5. Dec 2019 — Jan 2021 [monthly]

    Recruiting PHASE1

▶ Show 4 earlier versions

  1. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  2. Nov 2018 — Oct 2019 [monthly]

    Recruiting PHASE1

  3. Jun 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  4. Aug 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

    First recorded

Jul 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • First Affiliated Hospital, Sun Yat-Sen University
  • Guangdong Zhaotai InVivo Biomedicine Co. Ltd.
  • Hunan Zhaotai Yongren Medical Innovation Co. Ltd.
  • Second Affiliated Hospital of Guangzhou Medical University
Data source: Second Affiliated Hospital of Guangzhou Medical University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations