deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 4-arm NCT03206073

A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination With Immune Checkpoint Inhibition in Refractory Colorectal Cancer

Sponsor: National Cancer Institute (NCI)

Conditions Colorectal Adenocarcinoma Colorectal Cancer Colorectal Carcinoma Colorectal Neoplasms Refractory Cancer
Interventions Durvalumab Pexa-Vec Tremelimumab
Updated 27 times since 2017 Last updated: Sep 26, 2023 Started: Dec 7, 2017 Primary completion: Sep 24, 2020 Completion: Jun 30, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Colorectal Adenocarcinoma and Colorectal Cancer and is currently completed. National Cancer Institute (NCI) leads this study, which shows 27 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Mar 2018 · 3 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Dec 2018 · 4 months · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Apr 2019 · 3 months · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Feb 2020 · 4 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Nov 2020 · 3 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Nov 2021 · 9 months · monthly snapshot~Nov 2021 – ~Mar 2022 · 4 months · monthly snapshot~Mar 2022 – ~Feb 2023 · 11 months · monthly snapshot~Feb 2023 – ~Nov 2023 · 9 months · monthly snapshot~Nov 2023 – ~Jul 2024 · 8 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 21 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  3. Nov 2023 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

  4. Feb 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Mar 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

▶ Show 22 earlier versions

  1. Nov 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  2. Feb 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  3. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  4. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  5. Aug 2020 — Nov 2020 [monthly]

    Recruiting PHASE1_PHASE2

  6. Jun 2020 — Aug 2020 [monthly]

    Recruiting PHASE1_PHASE2

  7. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1_PHASE2

  8. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1_PHASE2

  9. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1_PHASE2

  10. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1_PHASE2

  11. Oct 2019 — Feb 2020 [monthly]

    Recruiting PHASE1_PHASE2

  12. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1_PHASE2

  13. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE1_PHASE2

  14. May 2019 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

  15. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1_PHASE2

  16. Jan 2019 — Apr 2019 [monthly]

    Recruiting PHASE1_PHASE2

  17. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1_PHASE2

  18. Aug 2018 — Dec 2018 [monthly]

    Recruiting PHASE1_PHASE2

  19. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1_PHASE2

  20. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  21. Dec 2017 — Mar 2018 [monthly]

    Recruiting PHASE1_PHASE2

  22. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations