deltatrials
Enrolling By Invitation PHASE4 INTERVENTIONAL 6-arm NCT03244020

LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology

Low Molecular Weight Heparin Versus Aspirin for Venous Thromboembolism Prophylaxis in Orthopaedic Oncology

Sponsor: Johns Hopkins University

Conditions Anticoagulant-induced Bleeding Bone Metastases Bone Sarcoma Hematoma Sarcoma Soft Tissue Sarcoma Venous Thromboembolism
Interventions Aspirin 325mg Enoxaparin 40Mg/0.4mL Prefilled Syringe
Updated 13 times since 2017 Last updated: Sep 30, 2025 Started: Feb 16, 2018 Primary completion: Dec 31, 2027 Completion: Jul 1, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Anticoagulant-induced Bleeding and Bone Metastases and is currently ongoing. Johns Hopkins University leads this study, which shows 13 recorded versions since 2018 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Aug 2017 – ~Apr 2018 · 8 months · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Mar 2020 · 21 months · monthly snapshot~Mar 2020 – ~Jan 2021 · 10 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~May 2022 · 14 months · monthly snapshot~May 2022 – ~Feb 2023 · 9 months · monthly snapshot~Feb 2023 – ~May 2024 · 15 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Nov 2025 · 9 months · monthly snapshot~Nov 2025 – present · 8 months · monthly snapshot

Change History

13 versions recorded

  1. Nov 2025 — Present [monthly]

    Enrolling By Invitation PHASE4

  2. Feb 2025 — Nov 2025 [monthly]

    Enrolling By Invitation PHASE4

  3. Sep 2024 — Feb 2025 [monthly]

    Enrolling By Invitation PHASE4

  4. Jul 2024 — Sep 2024 [monthly]

    Enrolling By Invitation PHASE4

  5. May 2024 — Jul 2024 [monthly]

    Enrolling By Invitation PHASE4

▶ Show 8 earlier versions

  1. Feb 2023 — May 2024 [monthly]

    Enrolling By Invitation PHASE4

  2. May 2022 — Feb 2023 [monthly]

    Enrolling By Invitation PHASE4

  3. Mar 2021 — May 2022 [monthly]

    Enrolling By Invitation PHASE4

  4. Jan 2021 — Mar 2021 [monthly]

    Enrolling By Invitation PHASE4

  5. Mar 2020 — Jan 2021 [monthly]

    Enrolling By Invitation PHASE4

  6. Jun 2018 — Mar 2020 [monthly]

    Enrolling By Invitation PHASE4

  7. Apr 2018 — Jun 2018 [monthly]

    Enrolling By Invitation PHASE4

    Status: Not Yet Recruiting → Enrolling By Invitation

  8. Aug 2017 — Apr 2018 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Johns Hopkins University
  • Massachusetts General Hospital
  • University of Missouri-Columbia
Data source: Massachusetts General Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations