deltatrials
Terminated PHASE2 INTERVENTIONAL 1-arm NCT03258008

Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer

Phase II Trial of Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer

Sponsor: ISA Pharmaceuticals B.V.

Updated 12 times since 2017 Last updated: Nov 22, 2022 Started: Apr 4, 2018 Primary completion: Nov 5, 2021 Completion: Nov 5, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Closed the trial for infeasibility due to slow accrual

Listed as NCT03258008, this PHASE2 trial focuses on Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites and Malignant Neoplasms of Lip Oral Cavity and Pharynx and remains terminated or withdrawn. Sponsored by ISA Pharmaceuticals B.V., it has been updated 12 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Sep 2017 – ~Mar 2018 · 6 months · monthly snapshotNot Yet Recruiting~Mar 2018 – ~May 2018 · 2 months · monthly snapshotNot Yet Recruiting~May 2018 – ~Jun 2018 · 31 days · monthly snapshotRecruiting~Jun 2018 – ~Jun 2019 · 12 months · monthly snapshotRecruiting~Jun 2019 – ~Feb 2020 · 8 months · monthly snapshotActive Not Recruiting~Feb 2020 – ~Jul 2020 · 5 months · monthly snapshotActive Not Recruiting~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshotActive Not Recruiting~Jan 2021 – ~Jul 2022 · 18 months · monthly snapshotActive Not Recruiting~Jul 2022 – ~Jan 2023 · 6 months · monthly snapshotCompleted~Jan 2023 – ~Jul 2024 · 18 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – present · 22 months · monthly snapshotTerminated

Change History

12 versions recorded
  1. Sep 2024 — Present [monthly]

    Terminated PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  3. Jan 2023 — Jul 2024 [monthly]

    Terminated PHASE2

    Status: CompletedTerminated

  4. Jul 2022 — Jan 2023 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  5. Jan 2021 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

Show 7 earlier versions
  1. Jul 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE2

  3. Jun 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  4. Jun 2018 — Jun 2019 [monthly]

    Recruiting PHASE2

  5. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  6. Mar 2018 — May 2018 [monthly]

    Not Yet Recruiting PHASE2

  7. Sep 2017 — Mar 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • ISA Pharmaceuticals B.V.
  • M.D. Anderson Cancer Center
  • Pfizer
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations