deltatrials
Terminated PHASE4 INTERVENTIONAL 2-arm NCT03258723

Diabetes Prevention With Lifestyle Intervention and Metformin Escalation (LIME)

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Conditions Diabetes
Interventions Lifestyle Intervention Metformin
Updated 15 times since 2017 Last updated: Feb 1, 2024 Started: Jul 30, 2018 Primary completion: Dec 1, 2021 Completion: Dec 1, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

COVID-19 led to changes in study design and an early end to data collection.

Other terminated trials from National Heart, Lung, and Blood Institute (NHLBI)

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This PHASE4 trial investigates Diabetes and is currently terminated or withdrawn. National Heart, Lung, and Blood Institute (NHLBI) leads this study, which shows 15 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Dec 2019 · 17 months · monthly snapshot~Dec 2019 – ~Apr 2020 · 4 months · monthly snapshot~Apr 2020 – ~Jan 2021 · 9 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Oct 2021 · 4 months · monthly snapshot~Oct 2021 – ~Jul 2022 · 9 months · monthly snapshot~Jul 2022 – ~Jan 2023 · 6 months · monthly snapshot~Jan 2023 – ~Mar 2024 · 14 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

15 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE4

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE4

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE4

  4. Mar 2024 — Jul 2024 [monthly]

    Terminated PHASE4

  5. Jan 2023 — Mar 2024 [monthly]

    Terminated PHASE4

    Status: Completed → Terminated

▶ Show 10 earlier versions

  1. Jul 2022 — Jan 2023 [monthly]

    Completed PHASE4

    Status: Active Not Recruiting → Completed

  2. Oct 2021 — Jul 2022 [monthly]

    Active Not Recruiting PHASE4

  3. Jun 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

  4. Jan 2021 — Jun 2021 [monthly]

    Recruiting PHASE4

  5. Apr 2020 — Jan 2021 [monthly]

    Recruiting PHASE4

  6. Dec 2019 — Apr 2020 [monthly]

    Recruiting PHASE4

    Status: Not Yet Recruiting → Recruiting

  7. Jul 2018 — Dec 2019 [monthly]

    Not Yet Recruiting PHASE4

  8. Jun 2018 — Jul 2018 [monthly]

    Not Yet Recruiting PHASE4

  9. Oct 2017 — Jun 2018 [monthly]

    Not Yet Recruiting PHASE4

    Phase: PHASE1_PHASE2 → PHASE4

  10. Sep 2017 — Oct 2017 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Heart, Lung, and Blood Institute (NHLBI)
  • National Institute on Minority Health and Health Disparities (NIMHD)
  • Yale University
Data source: Yale University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations