deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT03259503

Olaparib and High-Dose Chemotherapy in Treating Patients With Relapsed or Refractory Lymphomas Undergoing Stem Cell Transplant

Olaparib Combined With High-Dose Chemotherapy for Refractory Lymphomas

Sponsor: M.D. Anderson Cancer Center

Conditions Recurrent Diffuse Large B-Cell Lymphoma Recurrent T-Cell Non-Hodgkin Lymphoma Refractory Diffuse Large B-Cell Lymphoma Refractory Hodgkin Lymphoma Refractory T-Cell Non-Hodgkin Lymphoma
Interventions Busulfan Gemcitabine Melphalan Olaparib Peripheral Blood Stem Cell Transplantation Pharmacokinetic Study Rituximab Vorinostat
Updated 26 times since 2017 Last updated: Nov 7, 2025 Started: Sep 13, 2019 Primary completion: Nov 5, 2025 Completion: Nov 5, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Recurrent Diffuse Large B-Cell Lymphoma and Recurrent T-Cell Non-Hodgkin Lymphoma and is currently completed. M.D. Anderson Cancer Center leads this study, which shows 26 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Sep 2017 – ~Jun 2018 · 9 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Oct 2018 · 3 months · monthly snapshot~Oct 2018 – ~Feb 2019 · 4 months · monthly snapshot~Feb 2019 – ~Jun 2019 · 4 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Apr 2020 · 4 months · monthly snapshot~Apr 2020 – ~Jul 2020 · 3 months · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Mar 2022 · 14 months · monthly snapshot~Mar 2022 – ~May 2022 · 2 months · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~May 2023 · 8 months · monthly snapshot~May 2023 – ~Sep 2023 · 4 months · monthly snapshot~Sep 2023 – ~Apr 2024 · 7 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Apr 2025 · 6 months · monthly snapshot~Apr 2025 – ~Oct 2025 · 6 months · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

26 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Apr 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Oct 2024 — Apr 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 21 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2023 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  4. May 2023 — Sep 2023 [monthly]

    Recruiting PHASE1

  5. Sep 2022 — May 2023 [monthly]

    Recruiting PHASE1

  6. May 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  7. Mar 2022 — May 2022 [monthly]

    Recruiting PHASE1

  8. Jan 2021 — Mar 2022 [monthly]

    Recruiting PHASE1

  9. Jul 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  10. Apr 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  11. Dec 2019 — Apr 2020 [monthly]

    Recruiting PHASE1

  12. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  13. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  14. Sep 2019 — Oct 2019 [monthly]

    Not Yet Recruiting PHASE1

  15. Jul 2019 — Sep 2019 [monthly]

    Not Yet Recruiting PHASE1

    Phase: PHASE1_PHASE2 → PHASE1

  16. Jun 2019 — Jul 2019 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  17. Feb 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  18. Oct 2018 — Feb 2019 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  19. Jul 2018 — Oct 2018 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  20. Jun 2018 — Jul 2018 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  21. Sep 2017 — Jun 2018 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations