deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 3-arm NCT03263650

Study of Olaparib Maintenance Following Cabazitaxel-Carbo in Men With AVPC

Randomized Phase II Study of Olaparib Maintenance Following Cabazitaxel-Carboplatin Induction Chemotherapy in Men With Aggressive Variant Prostate Cancer (AVPC)

Sponsor: AstraZeneca

Conditions Prostate Cancer Aggressiveness Prostate Carcinoma
Interventions Cabazitaxel Carboplatin Olaparib Prednisone 5Mg
Updated 22 times since 2017 Last updated: Feb 13, 2026 Started: Oct 3, 2017 Primary completion: Jun 30, 2026 Completion: Jun 30, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Prostate Cancer Aggressiveness and Prostate Carcinoma, this trial is ongoing. The trial is conducted by AstraZeneca and has accumulated 22 data snapshots since 2017. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Feb 2019 · 8 months · monthly snapshot~Feb 2019 – ~Oct 2020 · 20 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Jun 2022 · 13 months · monthly snapshot~Jun 2022 – ~Jan 2023 · 7 months · monthly snapshot~Jan 2023 – ~Jun 2023 · 5 months · monthly snapshot~Jun 2023 – ~Nov 2023 · 5 months · monthly snapshot~Nov 2023 – ~Jun 2024 · 7 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Feb 2026 · 4 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

22 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Oct 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jun 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Mar 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 17 earlier versions

  1. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Nov 2023 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2

  7. Jun 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  8. Jan 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

  9. Jun 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE2

  10. May 2021 — Jun 2022 [monthly]

    Active Not Recruiting PHASE2

  11. Jan 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE2

  12. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  13. Feb 2019 — Oct 2020 [monthly]

    Recruiting PHASE2

  14. Jun 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  15. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  16. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  17. Sep 2017 — Oct 2017 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
  • M.D. Anderson Cancer Center
  • Merck Sharp & Dohme LLC
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations