deltatrials
Completed PHASE4 INTERVENTIONAL 2-arm NCT03266783

Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism (COBRRA)

Sponsor: Canadian Institutes of Health Research (CIHR)

Updated 24 times since 2017 Last updated: Nov 14, 2025 Started: Dec 13, 2017 Primary completion: Apr 30, 2025 Completion: Sep 8, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03266783, this PHASE4 trial focuses on Venous Thromboembolism and remains completed. Sponsored by Canadian Institutes of Health Research (CIHR), it has been updated 24 times since 2017, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Sep 2017 – ~Jan 2018 · 4 months · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Jan 2019 · 5 months · monthly snapshot~Jan 2019 – ~May 2019 · 4 months · monthly snapshot~May 2019 – ~Nov 2019 · 6 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Apr 2020 · 4 months · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Dec 2021 · 10 months · monthly snapshot~Dec 2021 – ~Apr 2022 · 4 months · monthly snapshot~Apr 2022 – ~May 2023 · 13 months · monthly snapshot~May 2023 – ~Nov 2023 · 6 months · monthly snapshot~Nov 2023 – ~May 2024 · 6 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~May 2025 · 6 months · monthly snapshot~May 2025 – ~Aug 2025 · 3 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 8 months · monthly snapshot

Change History

24 versions recorded
  1. Dec 2025 — Present [monthly]

    Completed PHASE4

    Status: Active Not RecruitingCompleted

  2. Sep 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE4

  3. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE4

  4. May 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE4

    Status: RecruitingActive Not Recruiting

  5. Nov 2024 — May 2025 [monthly]

    Recruiting PHASE4

Show 19 earlier versions
  1. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE4

  2. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE4

  3. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE4

  4. Nov 2023 — May 2024 [monthly]

    Recruiting PHASE4

  5. May 2023 — Nov 2023 [monthly]

    Recruiting PHASE4

  6. Apr 2022 — May 2023 [monthly]

    Recruiting PHASE4

  7. Dec 2021 — Apr 2022 [monthly]

    Recruiting PHASE4

  8. Feb 2021 — Dec 2021 [monthly]

    Recruiting PHASE4

  9. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE4

  10. Sep 2020 — Jan 2021 [monthly]

    Recruiting PHASE4

  11. Apr 2020 — Sep 2020 [monthly]

    Recruiting PHASE4

  12. Dec 2019 — Apr 2020 [monthly]

    Recruiting PHASE4

  13. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE4

  14. May 2019 — Nov 2019 [monthly]

    Recruiting PHASE4

  15. Jan 2019 — May 2019 [monthly]

    Recruiting PHASE4

  16. Aug 2018 — Jan 2019 [monthly]

    Recruiting PHASE4

  17. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE4

  18. Jan 2018 — Jun 2018 [monthly]

    Recruiting PHASE4

    Status: Not Yet RecruitingRecruiting

  19. Sep 2017 — Jan 2018 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Canadian Institutes of Health Research (CIHR)
  • Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network
  • Ottawa Hospital Research Institute
Data source: Ottawa Hospital Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .