deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT03274414

A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages

A Phase II, Single-Arm Trial Assessing Local Control of Near Total Endoscopic Resection Followed by Concurrent Chemotherapy and Proton Radiation in the Treatment of Unresectable Sinonasal Tumors

Sponsor: Memorial Sloan Kettering Cancer Center

Conditions Nasal Cavity Adenocarcinoma Nasal Cavity Tumor Paranasal Sinus Cancer
Interventions Adjuvant Proton Radiotherapy Cisplatin Endoscopic Resection cisplatin and etoposide
Updated 16 times since 2017 Last updated: May 8, 2025 Started: Sep 1, 2017 Primary completion: Jan 13, 2023 Completion: Jan 13, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Nasal Cavity Adenocarcinoma and Nasal Cavity Tumor, this trial is completed. The trial is conducted by Memorial Sloan Kettering Cancer Center and has accumulated 16 data snapshots since 2017. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Feb 2019 · 3 months · monthly snapshot~Feb 2019 – ~Jan 2020 · 11 months · monthly snapshot~Jan 2020 – ~Jun 2020 · 5 months · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Sep 2022 · 12 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Nov 2023 · 9 months · monthly snapshot~Nov 2023 – ~Jul 2024 · 8 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshot~Jun 2025 – present · 13 months · monthly snapshot

Change History

16 versions recorded

  1. Jun 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Jun 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Nov 2023 — Jul 2024 [monthly]

    Completed PHASE2

  5. Feb 2023 — Nov 2023 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

▶ Show 11 earlier versions

  1. Sep 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2021 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  4. Aug 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  5. Jun 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  6. Jan 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  7. Feb 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  8. Nov 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  9. Sep 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  10. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  11. Oct 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

    First recorded

Sep 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Memorial Sloan Kettering Cancer Center
Data source: Memorial Sloan Kettering Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations